RANBP10 - RAN binding protein 10 Gene

中文名称：RAN 结合蛋白 10

种属: Homo sapiens

关于 RANBP10

功能概要

RAN 是一种参与微管组装形成有丝分裂纺锤体的小 GTP 酶。由该基因编码的蛋白质是一种细胞质鸟嘌呤核苷酸交换因子 (GEF) ，可结合 β-微管蛋白并具有针对 RAN 的 GEF 活性。编码的蛋白质在非中心体微管的形成中起作用。此外，该蛋白可能参与蛋白激酶 C 三角洲和蛋白激酶 C 伽马对 D (1) 受体信号的调节。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2016 年 2 月]

RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]