SEMA4G - semaphorin 4G Gene

中文名称：信号素 4G

种属: Homo sapiens

关于 SEMA4G

功能概要

信号蛋白是一大类保守的分泌蛋白和膜相关蛋白，其在 N 末端胞外部分具有信号蛋白 (Sema) 结构域和 PSI 结构域 (存在于丛蛋白、信号蛋白和整联蛋白中) 。基于序列和结构的相似性，信号蛋白分为八类：无脊椎动物包含第 1 类和第 2 类，病毒包含第 V 类，脊椎动物包含第 3-7 类。信号蛋白通过多聚体受体复合物充当轴突引导配体，其中一些 (如果不是全部) 含有丛蛋白。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 2 月]

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]