2. Gene
  3. PTPRJ - protein tyrosine phosphatase receptor type J Gene

PTPRJ - protein tyrosine phosphatase receptor type J Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：J 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: DEP1; SCC1; CD148; HPTPeta; R-PTP-J; HPTP eta; R-PTP-ETA

基因 ID: 5795 | 基因类型: protein coding

关于 PTPRJ

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,980,559-48,170,839 (from NCBI)

This gene has 7 transcripts (splice variants), 214 orthologues, 35 paralogues and is associated with 1 phenotype. Broad expression in thyroid (RPKM 11.4), appendix (RPKM 10.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 具有包含五个纤连蛋白 III 型重复序列的胞外区、单个跨膜区和单个胞质内催化结构域，因此代表受体型 PTP。这种蛋白质存在于所有造血细胞谱系中，并显示可能通过干扰磷脂酶 C Gamma 1 和激活 T 细胞的连接子的磷酸化来负向调节 T 细胞受体信号。这种蛋白质还可以使 PDGF β 受体去磷酸化，并可能参与紫外线诱导的信号转导。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTPRJ 基因产物(2)

mRNA Protein Name
NM_001098503.2 NP_001091973.1 receptor-type tyrosine-protein phosphatase eta isoform 2 precursor
NM_002843.4 NP_002834.3 receptor-type tyrosine-protein phosphatase eta isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-catenin binding IPI
IPI: 通过物理相互作用推断
12370829 GOA
enables cadherin binding IPI
IPI: 通过物理相互作用推断
28926625 GOA
enables delta-catenin binding IPI
IPI: 通过物理相互作用推断
12370829 GOA
enables gamma-catenin binding IPI
IPI: 通过物理相互作用推断
12370829 GOA
enables mitogen-activated protein kinase binding IPI
IPI: 通过物理相互作用推断
19494114 GOA
enables phosphatase activity IDA
IDA: 通过直接分析推断
12062403 GOA
enables phosphatase activity IMP
IMP: 通过突变表型推断
11259588 GOA
enables platelet-derived growth factor receptor binding IPI
IPI: 通过物理相互作用推断
10821867 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10821867 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
19332538 GOA
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
9531590 GOA
enables protein tyrosine phosphatase activity IMP
IMP: 通过突变表型推断
9780142 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
19494114 GOA
involved in negative regulation of T cell receptor signaling pathway IDA
IDA: 通过直接分析推断
12913111 GOA
involved in negative regulation of T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
9780142 GOA
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
14709717 GOA
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
16682945 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
14709717 GOA
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
19836242 GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
19922411 GOA
involved in negative regulation of platelet-derived growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
14709717 GOA
involved in negative regulation of vascular permeability IDA
IDA: 通过直接分析推断
19332538 GOA
involved in peptidyl-tyrosine dephosphorylation IDA
IDA: 通过直接分析推断
9531590 GOA
involved in peptidyl-tyrosine dephosphorylation IMP
IMP: 通过突变表型推断
9780142 GOA
involved in platelet formation IMP
IMP: 通过突变表型推断
30591527 GOA
involved in platelet-derived growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
21091576 GOA
involved in positive chemotaxis IDA
IDA: 通过直接分析推断
14709717 GOA
involved in positive regulation of cell adhesion IMP
IMP: 通过突变表型推断
21091576 GOA
involved in positive regulation of focal adhesion assembly IMP
IMP: 通过突变表型推断
21091576 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
18936167 GOA
involved in regulation of cell adhesion IMP
IMP: 通过突变表型推断
12370829 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
12913111 GOA
located in cell-cell junction IDA
IDA: 通过直接分析推断
12370829 GOA
located in immunological synapse IDA
IDA: 通过直接分析推断
12913111 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
9531590 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTPRJ 蛋白结构

fn3

fn3: Fibronectin type III domain (120 - 187)

fn3

fn3: Fibronectin type III domain (369 - 437)

fn3

fn3: Fibronectin type III domain (541 - 606)

fn3

fn3: Fibronectin type III domain (626 - 704)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (1065 - 1296)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1337 a.a.
蛋白主名 其他名称

receptor-type tyrosine-protein phosphatase eta

CD148 antigen

PTPRJ 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PTPRJ Q12913 KDR Homo sapiens P35968
Pull Down
18936167
种属内
PTPRJ Q12913 KDR Homo sapiens P35968
CoIP
18936167
种属内
PTPRJ Q12913 FLT1 Homo sapiens P17948
Biochemical
16893970
种属内
PTPRJ Q12913 MET Homo sapiens P08581
Affinity Chrom
12475979
种属内
PTPRJ Q12913 MET Homo sapiens P08581
Phosphatase Assay
19167335
种属内
PTPRJ Q12913 MET Homo sapiens P08581
CoIP
12475979
种属内
PTPRJ Q12913 TEK Homo sapiens Q02763
Phosphatase Assay
19167335
种属内
PTPRJ Q12913 GHR Homo sapiens P10912
Phosphatase Assay
19167335
种属内
PTPRJ Q12913 CTNNB1 Homo sapiens P35222
Phosphatase Assay
19167335
种属内
PTPRJ Q12913 CTNNB1 Homo sapiens P35222
Pull Down
12370829
种属内
PTPRJ Q12913 GAB1 Homo sapiens Q13480
Pull Down
12475979
种属内
PTPRJ Q12913 GAB1 Homo sapiens Q13480
Phosphatase Assay
19167335
种属内
PTPRJ Q12913 ERBB2 Homo sapiens P04626
Phosphatase Assay
19167335
种属内
PTPRJ Q12913 PDGFRB Homo sapiens P09619
Phosphatase Assay
19167335
种属内
PTPRJ Q12913 CTNND1 Homo sapiens O60716
Pull Down
12475979
种属内
PTPRJ Q12913 CTNND1 Homo sapiens O60716
Pull Down
12370829
种属内
PTPRJ Q12913 CTNND1 Homo sapiens O60716
Biochemical
12370829
种属内
PTPRJ Q12913 CTNND1 Homo sapiens O60716
Fluorescence
12370829
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PTPRJ 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74200 DEP-1/CD148 Protein, Human (341a.a, His) Q12913-1 (R997-A1337) ≥95%

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Interstitial Keratitis
Cogan Syndrome

Cogan'S Syndrome

Diffuse Interstitual Keratitis

Cogans Syndrome

Oculovestibuloauditory Syndrome
Cd45 Deficiency
Thrombosis

Thrombosis Of Blood Vessel
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Methotrexate-Associated Lymphoproliferation
Hyperinsulinemic Hypoglycemia, Familial, 1

HHF1

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Familial Hyperinsulinemic Hypoglycemia 1

Congenital Hyperinsulinism

Phhi

Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency

Hypoglycemia, Hyperinsulinemic, Of Infancy

Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia

Nesidioblastosis Of Pancreas

Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis

Hyperinsulinism, Congenital

Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency

Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form

Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency

Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

Hypoglycemia, Hyperinsulinemic, Familial, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11441 PTPRJ Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PTPRJ VGNC VGNC:106883
Felis catus PTPRJ VGNC VGNC:69175
Rattus norvegicus PTPRJ RGD RGD:3454
Macaca mulatta PTPRJ VGNC VGNC:76618
Canis familiaris PTPRJ VGNC VGNC:45190
Mus musculus PTPRJ MGD MGI:104574
Others PTPRJ NCBI
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