RAB13 - RAB13, member RAS oncogene family Gene

中文名称：RAB13，RAS 致癌基因家族成员

种属: Homo sapiens

同用名: GIG4

关于 RAB13

功能概要

该基因是小 G 蛋白 Rab 家族的成员，在调节跨高尔基体网络 (TGN) 和再循环核内体 (RE) 之间的膜运输中发挥作用。编码的蛋白质参与紧密连接的组装，紧密连接是上皮细胞顶端连接复合体 (AJC) 的组成部分。 AJC 在管腔内容物和下层组织之间形成屏障方面发挥作用。与蛋白质相关的其他功能包括 occludin 的内吞循环、上皮细胞分散的调节、神经元再生和神经突长出的调节。已经观察到该基因的交替剪接转录物变体。与该基因相关的假基因位于 12 号染色体上。[RefSeq 提供，2013 年 1 月]

This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]