2. Gene
  3. Smpd3 - sphingomyelin phosphodiesterase 3, neutral Gene

Smpd3 - sphingomyelin phosphodiesterase 3, neutral Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: fro; nSMase2; 4631433G07Rik

基因 ID: 58994 | 基因类型: protein coding

关于 Smpd3

功能概要

Enables identical protein binding activity; neutral sphingomyelin phosphodiesterase activity; and phospholipid binding activity. Involved in sphingomyelin metabolic process. Acts upstream of or within several processes, including animal organ development; Enzyme linked receptor protein signaling pathway; and sphingolipid metabolic process. Located in Golgi cis cisterna and plasma membrane. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and skeleton. Used to study hypopituitarism; osteogenesis imperfecta; osteogenesis imperfecta type 2; and osteogenesis imperfecta type 3. Orthologous to human SMPD3 (sphingomyelin phosphodiesterase 3). [provided by Alliance of Genome Resources, Apr 2022]

Smpd3 基因产物(1)

mRNA Protein Name
NM_021491.4 NP_067466.1 sphingomyelin phosphodiesterase 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25287744 MGI
enables neutral sphingomyelin phosphodiesterase activity IDA
IDA: 通过直接分析推断
16025116 MGI
enables phosphatidic acid binding IDA
IDA: 通过直接分析推断
21550973 MGI
enables phosphatidylserine binding IDA
IDA: 通过直接分析推断
21550973 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
20080539 MGI
enables sphingomyelin phosphodiesterase activity IDA
IDA: 通过直接分析推断
10823942 MGI
enables sphingomyelin phosphodiesterase activity IMP
IMP: 通过突变表型推断
15764706 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within BMP signaling pathway IDA
IDA: 通过直接分析推断
24505141 MGI
acts upstream of or within DNA biosynthetic process IMP
IMP: 通过突变表型推断
23651497 MGI
acts upstream of or within G1 to G0 transition IMP
IMP: 通过突变表型推断
23046545 MGI
acts upstream of or within bone development IMP
IMP: 通过突变表型推断
27325675 MGI
acts upstream of or within bone growth IMP
IMP: 通过突变表型推断
17626887 MGI
acts upstream of or within bone mineralization IDA
IDA: 通过直接分析推断
21788370 MGI
acts upstream of or within bone mineralization IMP
IMP: 通过突变表型推断
21788370 MGI
acts upstream of or within cartilage development IDA
IDA: 通过直接分析推断
27325675 MGI
acts upstream of or within cartilage development IMP
IMP: 通过突变表型推断
17591962 MGI
acts upstream of or within cellular response to hydrogen peroxide IDA
IDA: 通过直接分析推断
23651497 MGI
acts upstream of or within cellular response to magnesium ion IDA
IDA: 通过直接分析推断
23973266 MGI
acts upstream of or within cellular response to oxidised low-density lipoprotein particle stimulus IMP
IMP: 通过突变表型推断
20352118 MGI
acts upstream of or within cellular response to peptide IMP
IMP: 通过突变表型推断
27325675 MGI
acts upstream of or within cellular response to reactive oxygen species IMP
IMP: 通过突变表型推断
17561096 MGI
acts upstream of or within cellular response to redox state IMP
IMP: 通过突变表型推断
25287744 MGI
acts upstream of or within cellular response to tumor necrosis factor IMP
IMP: 通过突变表型推断
16025116 MGI
acts upstream of or within ceramide metabolic process IMP
IMP: 通过突变表型推断
22383528 MGI
acts upstream of or within chondrocyte development IMP
IMP: 通过突变表型推断
17591962 MGI
acts upstream of or within chondrocyte development involved in endochondral bone morphogenesis IMP
IMP: 通过突变表型推断
21788370 MGI
acts upstream of or within collagen metabolic process IMP
IMP: 通过突变表型推断
22910579 MGI
acts upstream of or within dentinogenesis IMP
IMP: 通过突变表型推断
16025116 MGI
acts upstream of or within endochondral ossification IMP
IMP: 通过突变表型推断
17591962 MGI
acts upstream of or within extracellular matrix assembly IMP
IMP: 通过突变表型推断
22910579 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: 通过突变表型推断
24029230 MGI
acts upstream of or within lung alveolus development IMP
IMP: 通过突变表型推断
22945695 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
22945695 MGI
acts upstream of or within mitotic nuclear division IMP
IMP: 通过突变表型推断
20352118 MGI
acts upstream of or within multicellular organism growth IDA
IDA: 通过直接分析推断
24585429 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
24585429 MGI
acts upstream of or within negative regulation of hyaluronan biosynthetic process IMP
IMP: 通过突变表型推断
22383528 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
24505141 MGI
acts upstream of or within ossification IMP
IMP: 通过突变表型推断
16025116 MGI
acts upstream of or within peptide hormone secretion IMP
IMP: 通过突变表型推断
15764706 MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
23651497 MGI
acts upstream of or within polysaccharide transport IMP
IMP: 通过突变表型推断
22383528 MGI
acts upstream of or within positive regulation of mitotic nuclear division IGI
IGI: 通过遗传相互作用推断
23651497 MGI
acts upstream of or within positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
17561096 MGI
acts upstream of or within regulation of cartilage development IMP
IMP: 通过突变表型推断
24505141 MGI
acts upstream of or within regulation of hyaluronan biosynthetic process IMP
IMP: 通过突变表型推断
22383528 MGI
acts upstream of or within regulation of leukocyte migration IMP
IMP: 通过突变表型推断
28377412 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
22383528 MGI
acts upstream of or within respiratory system development IMP
IMP: 通过突变表型推断
22945695 MGI
acts upstream of or within signal transduction IMP
IMP: 通过突变表型推断
17561096 MGI
acts upstream of or within skeletal system development IDA
IDA: 通过直接分析推断
24585429 MGI
acts upstream of or within skeletal system development IMP
IMP: 通过突变表型推断
17591962 MGI
acts upstream of or within sphingolipid mediated signaling pathway IDA
IDA: 通过直接分析推断
23651497 MGI
acts upstream of or within sphingolipid metabolic process IMP
IMP: 通过突变表型推断
22945695 MGI
acts upstream of or within sphingomyelin catabolic process IMP
IMP: 通过突变表型推断
23973266 MGI
acts upstream of or within sphingomyelin metabolic process IDA
IDA: 通过直接分析推断
10823942 MGI
involved in sphingomyelin metabolic process IDA
IDA: 通过直接分析推断
21550973 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
10823942 MGI
located in Golgi cis cisterna IDA
IDA: 通过直接分析推断
15764706 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
21550973 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sphingomyelin phosphodiesterase 3

nSMase-2

neutral sphingomyelinase 2

neutral sphingomyelinase II

Smpd3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Smpd3 Q9JJY3 HSPD1 Homo sapiens P10809
Anti Bait CoIP
23840630
种属间
Smpd3 Q9JJY3 HSPD1 Homo sapiens P10809
PLA
23840630
种属间
Smpd3 Q9JJY3 EED Homo sapiens O75530
Y2H
20080539
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13449 SMPD3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smpd3 NCBI NCBI:55512
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