RGS13 - regulator of G protein signaling 13 Gene

中文名称：G 蛋白信号调节器 13

种属: Homo sapiens

关于 RGS13

功能概要

由该基因编码的蛋白质是 G 蛋白信号转导 (RGS) 家族调节因子的成员。 RGS 家族成员与酿酒酵母 SST2 和秀丽隐杆线虫 egl-10 蛋白具有相似性，后者包含一个特征性的保守 RGS 结构域。 RGS 蛋白可加速 G 蛋白 α 亚基的 GTPase 活性，从而将 G 蛋白驱动为其无活性的 GDP 结合形式，从而负向调节 G 蛋白信号传导。 RGS 蛋白与响应 G 蛋白偶联受体激活的各种细胞事件的微调有关。然而，该基因的生物学功能尚不清楚。存在编码相同异构体的两个转录本变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]