Grm8 - glutamate metabotropic receptor 8 Gene

中文名称：谷氨酸代谢受体 8

种属: Rattus norvegicus

同用名: Glur8; mGlur; Gprc1h; Mglur8; mGluR8b

关于 Grm8

功能概要

该基因编码的蛋白可启动 III 组代谢型谷氨酸受体活性。参与检测参与疼痛感官知觉的机械刺激；谷氨酸能突触传递；和突触小泡胞吐的调节。位于神经元投射；神经细胞体；和突触前膜。是质膜的组成部分。在 GABA 能突触和谷氨酸能突触中活跃。是突触前活动区膜的组成部分。用于研究帕金森症；癫痫;和视觉性癫痫。该基因的人类直系同源物与注意力缺陷多动障碍有关；自闭症；和精神分裂症。与人类 GRM8（谷氨酸代谢受体 8）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables group III metabotropic glutamate receptor activity. Involved in detection of mechanical stimulus involved in sensory perception of pain; glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Located in neuron projection; neuronal cell body; and presynaptic membrane. Is integral component of plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of presynaptic active zone membrane. Used to study Parkinsonism; epilepsy; and visual epilepsy. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8). [provided by Alliance of Genome Resources, Apr 2022]