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  2. RPL15 - ribosomal protein L15 Gene

RPL15 - ribosomal protein L15 Gene

中文名称:核糖体蛋白 L15

种属: Homo sapiens

同用名: L15; EC45; DBA12; RPL10; RPLY10; RPYL10

基因 ID: 6138 | 基因类型: protein coding

关于 RPL15

Cytogenetic location: 3p24.2 Genomic coordinates (GRCh38): 3:23,916,545-23,924,631 (from NCBI)

This gene has 16 transcripts (splice variants), 160 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 335.5), thyroid (RPKM 183.2) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器,由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由四种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码核糖体蛋白 L15E 家族的一个成员和 60S 亚基的一个组成部分。该基因与酵母核糖体蛋白 YL10 基因具有序列相似性。已在食管肿瘤和胃癌组织中观察到该基因的表达升高,并且已在 Diamond-Blackfan 贫血 (DBA) 患者中观察到该基因的缺失。作为典型的编码核糖体蛋白的基因,该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供,2017 年 3 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric Cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]

RPL15 基因产物(6)

mRNA Protein Name
NM_001253379.2 NP_001240308.1 60S ribosomal protein L15 isoform 1
NM_001253380.2 NP_001240309.1 60S ribosomal protein L15 isoform 1
NM_001253382.2 NP_001240311.1 60S ribosomal protein L15 isoform 1
NM_001253383.3 NP_001240312.1 60S ribosomal protein L15 isoform 1
NM_001253384.2 NP_001240313.1 60S ribosomal protein L15 isoform 2
NM_002948.5 NP_002939.2 60S ribosomal protein L15 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21612406 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cytosolic large ribosomal subunit IDA
IDA: 通过直接分析推断
32669547 GOA
part of cytosolic large ribosomal subunit IPI
IPI: 通过物理相互作用推断
25901680 GOA
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
located in nucleus IDA
IDA: 通过直接分析推断
25468996 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RPL15 蛋白结构

Ribosomal_L15e

Ribosomal_L15e: Ribosomal L15 (2 - 193)

  • 0
  • 100
  • 204 a.a.
蛋白主名 其他名称

60S ribosomal protein L15

large ribosomal subunit protein eL15

RPL15 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPL15 P61313 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
RPL15 P61313 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
RPL15 P61313 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
RPL15 P61313 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
种属内
RPL15 P61313 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diamond-Blackfan Anemia 12

DBA12

Rpl15-Related Diamond-Blackfan Anemia

Anemia, Diamond-Blackfan, Type 12

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome

Macrocytic Anemia

Anemia Macrocytic

Anemia, Macrocytic

Macrocytic Anaemia

Pontocerebellar Hypoplasia, Type 15

PCH15

Pontocerebellar Hypoplasia Type 15

Pontocerebellar Hypoplasia 15

Doid:0112326

Pierre Robin Syndrome

Pierre Robin Sequence

Glossoptosis, Micrognathia, And Cleft Palate

Pierre Robin Syndrome Skeletal Dysplasia Polydactyly

Pierre-Robin Syndrome

Isolated Pierre Robin Sequence

Isolated Pierre-Robin Syndrome

PRBNS

Robin Sequence

Robin Syndrome

Isolated Pierre Robin Syndrome

Anemia, X-Linked, With Or Without Neutropenia And/Or Platelet Abnormalities

X-Linked Dyserythropoietic Anemia

X-Linked Dyserythropoietic Anemia With Abnormal Platelets And Neutropenia

XLANP

Anemia, X-Linked, With/Without Neutropenia And/Or Platelet Abnormalities

X-Linked Anemia With/Without Neutropenia And/Or Platelet Abnormalities

Anemia Without Thrombocytopenia, X-Linked

XLAWT

Anemia X-Linked With Variable Neutropenia

Retinitis Pigmentosa 10

RP10

Retinitis Pigmentosa-10

Retinitis Pigmentosa, Type 10

Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome

Shwachman Syndrome

Shwachman-Bodian-Diamond Syndrome

Sds

Pancreatic Insufficiency And Bone Marrow Dysfunction

Shwachman-Bodian Syndrome

SDS1

Lipomatosis Of Pancreas, Congenital

Congenital Lipomatosis Of Pancreas

Shwachman-Diamond Type Metaphyseal Dysplasia

Metaphyseal Chondrodysplasia, Shwachman Type

Shwachman-Diamond-Oski Syndrome

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus RPL15 VGNC VGNC:102831
Mus musculus RPL15 MGD MGI:1913730
Canis familiaris RPL15 VGNC VGNC:52901
Rattus norvegicus RPL15 RGD RGD:621181