KIF13A - kinesin family member 13A Gene

中文名称：驱动蛋白家族成员 13A

种属: Homo sapiens

同用名: RBKIN; bA500C11.2

关于 KIF13A

功能概要

该基因编码基于微管的运动蛋白的驱动蛋白家族成员，该家族在定位核内体中发挥作用。该家族成员可以将含有 6-磷酸甘露糖受体的囊泡从反式高尔基体网络引导至质膜，并且对于晚期内体/溶酶体的稳态分布是必要的。在胞质分裂过程中，FYVE-CENT 和 TTC19 从中心体转移到中体也是必需的，并且它在黑素体成熟中发挥作用。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the Kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]