SEMG1 - semenogelin 1 (the main protein of the human semen coagulum) Gene

中文名称：semenogelin 1 (人类精液凝固的主要蛋白质)

种属: Homo sapiens

同用名: SGI; SEMG; CT103; dJ172H20.2

关于 SEMG1

功能概要

由该基因编码的蛋白质是精液中的主要蛋白质。编码的分泌蛋白参与包裹射精精子的凝胶基质的形成。这种前原蛋白由前列腺特异性抗原 (PSA) 蛋白酶进行蛋白水解处理，以生成具有不同功能的多种肽产物。其中一种肽 SgI-29 是一种具有抗菌活性的抗菌肽。这种蛋白水解过程还会分解凝胶基质，使精子能够更自由地移动。该基因和另一个类似的 semenogelin 基因存在于 20 号染色体上的基因簇中。[RefSeq 提供，2016 年 2 月]

The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these Peptides, SgI-29, is an antimicrobial peptide with Antibacterial activity. This proteolysis process also breaks down the gel matrix and allows the spermatozoa to move more freely. This gene and another similar semenogelin gene are present in a gene cluster on chromosome 20. [provided by RefSeq, Feb 2016]