2. Gene
  3. STXBP3 - syntaxin binding protein 3 Gene

STXBP3 - syntaxin binding protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：突触融合蛋白结合蛋白 3

种属: Homo sapiens

同用名: PSP; MUNC18C; UNC-18C; MUNC18-3

基因 ID: 6814 | 基因类型: protein coding

关于 STXBP3

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:108,746,674-108,809,523 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 25.5), kidney (RPKM 20.8) and 25 other tissues.

功能概要

启用 syntaxin 绑定活动。参与钙离子依赖性胞吐的负调节；中性粒细胞脱颗粒；和血小板聚集。位于胞质溶胶中；质膜;和分泌颗粒。在突触前活跃。 [由基因组资源联盟提供，2022 年 4 月]

Enables syntaxin binding activity. Involved in negative regulation of calcium ion-dependent exocytosis; neutrophil degranulation; and platelet aggregation. Located in cytosol; plasma membrane; and secretory granule. Is active in presynapse. [provided by Alliance of Genome Resources, Apr 2022]

STXBP3 基因产物(1)

mRNA Protein Name
NM_007269.4 NP_009200.2 syntaxin-binding protein 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12773094 GOA
enables syntaxin binding IPI
IPI: 通过物理相互作用推断
12773094 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of calcium ion-dependent exocytosis IMP
IMP: 通过突变表型推断
12649283 GOA
involved in neutrophil degranulation IEP
IEP: 通过表达模式推断
18588921 GOA
involved in platelet aggregation IMP
IMP: 通过突变表型推断
12773094 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
18588921 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
18588921 GOA
located in platelet alpha granule IDA
IDA: 通过直接分析推断
12773094 GOA
located in specific granule IDA
IDA: 通过直接分析推断
18588921 GOA
located in tertiary granule IDA
IDA: 通过直接分析推断
18588921 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STXBP3 蛋白结构

Sec1

Sec1: Sec1 family (32 - 576)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 592 a.a.
蛋白主名 其他名称

syntaxin-binding protein 3

platelet Sec1 protein

重组 STXBP3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74535 STXBP3 Protein, Human (sf9, His-GST) O00186 (M1-E592) ≥95%

关联疾病

疾病名称 别名
Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13991 STXBP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris STXBP3 VGNC VGNC:46961
Macaca mulatta STXBP3 VGNC VGNC:78051
Felis catus STXBP3 VGNC VGNC:65820
Rattus norvegicus STXBP3 RGD RGD:619968
Mus musculus STXBP3 MGD MGI:107362
Bos taurus STXBP3 VGNC VGNC:35447
Others STXBP3 NCBI
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