SUPT5H - SPT5 homolog, DSIF elongation factor subunit Gene

中文名称：SPT5 同系物，DSIF 延伸因子亚单位

种属: Homo sapiens

同用名: SPT5; SPT5H; Tat-CT1

基因 ID: 6829 | 基因类型: protein coding

关于 SUPT5H

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,445,582-39,476,670 (from NCBI)

This gene has 20 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 64.5), bone marrow (RPKM 32.4) and 25 other tissues.

功能概要

启用酶结合活性和蛋白质异二聚化活性。参与巨自噬的正调控；调节 RNA 代谢过程；和 RNA 聚合酶 II 启动子的转录延伸。位于核质中。 DSIF 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables Enzyme binding activity and protein heterodimerization activity. Involved in positive regulation of macroautophagy; regulation of RNA metabolic process; and transcription elongation from RNA polymerase II promoter. Located in nucleoplasm. Part of DSIF complex. [provided by Alliance of Genome Resources, Apr 2022]

SUPT5H 基因产物(12)

mRNA	Protein	Name
NM_001111020.3	NP_001104490.1	transcription elongation factor SPT5 isoform a
NM_001130824.2	NP_001124296.1	transcription elongation factor SPT5 isoform a
NM_001130825.2	NP_001124297.1	transcription elongation factor SPT5 isoform b
NM_001319990.2	NP_001306919.1	transcription elongation factor SPT5 isoform a
NM_001319991.2	NP_001306920.1	transcription elongation factor SPT5 isoform b
NM_003169.4	NP_003160.2	transcription elongation factor SPT5 isoform a
NM_001111020.3	NP_001104490.1	transcription elongation factor SPT5 isoform a
NM_001130824.2	NP_001124296.1	transcription elongation factor SPT5 isoform a
NM_001130825.2	NP_001124297.1	transcription elongation factor SPT5 isoform b
NM_001319990.2	NP_001306919.1	transcription elongation factor SPT5 isoform a
NM_001319991.2	NP_001306920.1	transcription elongation factor SPT5 isoform b
NM_003169.4	NP_003160.2	transcription elongation factor SPT5 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IPI IPI: 通过物理相互作用推断	10075709	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10075709	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	9450929	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription, elongation	IDA IDA: 通过直接分析推断	9450929	GOA
involved in negative regulation of DNA-templated transcription, elongation	IMP IMP: 通过突变表型推断	10075709	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9450929	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	10075709	GOA
involved in positive regulation of DNA-templated transcription, elongation	IDA IDA: 通过直接分析推断	9450929	GOA
involved in positive regulation of macroautophagy	IMP IMP: 通过突变表型推断	22354037	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9450929	GOA
involved in regulation of transcription elongation by RNA polymerase II	IDA IDA: 通过直接分析推断	9450929	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: 通过直接分析推断	9450929	GOA
involved in transcription elongation by RNA polymerase II	IMP IMP: 通过突变表型推断	10075709	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of DSIF complex	IDA IDA: 通过直接分析推断	9450929	GOA
part of DSIF complex	IPI IPI: 通过物理相互作用推断	19860741	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9450929	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SUPT5H 蛋白结构

Spt5_N

Spt5-NGN

KOW

CTD

0
200
400
600
800
1000
1087 a.a.

蛋白主名

其他名称

transcription elongation factor SPT5

DRB sensitivity-inducing factor 160 kDa subunit

SUPT5H 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	Far-WB	10075709
种属内	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	MAPPIT	25416956
种属内	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	Anti Bait CoIP	10075709
种属内	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	26496610
种属内	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	35271311
种属内	SUPT5H	O00267	PPIA	Homo sapiens	P62937	Pull Down	16169070
种属内	SUPT5H	O00267	PPIA	Homo sapiens	P62937	Y2H Pooling	16169070
种属内	SUPT5H	O00267	TERF1	Homo sapiens	P54274	Pull Down	21044950
种属内	SUPT5H	O00267	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
种属内	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Anti Tag CoIP	35271311
种属内	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	BFG-2H	27107012
种属内	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	TAP	24981860
种属内	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Anti Tag CoIP	26496610
种属内	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Crosslink	26789250
种属内	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Pull Down	10075709
种属内	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Y2H Array	31515488
种属内	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	MAPPIT	25416956
种属内	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	GMS	17404243
种属间	SUPT5H	O00267	POLR2B	Bos taurus	A5PJW8	Crosslink	26789250
种属间	SUPT5H	O00267	PA	Influenza A virus	Q5EP34	Anti Tag CoIP	21715506
种属间	SUPT5H	O00267	POLR2A	Bos taurus	G3MZY8	Crosslink	26789250

种属间: 跨种属相互作用 种属内: 同种属相互作用

SUPT5H 抗体

目录号	产品名	应用	反应物种
HY-P83159	SPT5 Antibody (YA2904)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

关联疾病

疾病名称

别名

Immunodeficiency With Hyper-Igm, Type 2

HIGM2	Hyper-Igm Syndrome Type 2
Hyper-Igm Syndrome 2	Immunodeficiency With Hyper-Igm Type 2
Activation-Induced Cytidine Deaminase Deficiency	Aid Deficiency
Immunodeficiency With Hyper Igm Type 2	Hyper Igm Syndrome 2
Immunodeficiency With Hyper-Igm 2	Hyper-Igm Immunodeficiency Type 2
Immunodeficiency, With Hyper Igm, Type 2	Hyper-Igm Immunodeficiency Syndrome, Type 2

Ichthyosis, Congenital, Autosomal Recessive 11

Autosomal Recessive Congenital Ichthyosis 11	Ichthyosis With Hypotrichosis, Autosomal Recessive
Arih	Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis
Autosomal Recessive Ichthyosis With Hypotrichosis	ARCI11
Ifah	Hypotrichosis-Congenital Ichthyosis Syndrome
Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome	Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome
Ichthyosis-Hypotrichosis Syndrome	Ifah Syndrome
Ihs

Immunodeficiency With Hyper-Igm, Type 1

Immunodeficiency, X-Linked, With Hyper-Igm	Hyper Igm Syndrome
HIGM1	Xhim
Hyper-Igm Syndrome	Higm
Hyper-Igm Syndrome 1	Immunodeficiency 3
Imd3	Immunodeficiency With Hyper-Igm
Immunodeficiency With Hyper Igm Type 1	Ihis
X-Linked Hyper Igm Syndrome	Hyper-Igm Immunodeficiency, X-Linked
Hyper Igm Immunodeficiency, X-Linked	Hyper Igm Syndrome 1
X-Linked Immunodeficiency With Hyper-Igm 1	Immunodeficiency, With Hyper Igm
Immunodeficiency, With Hyper Igm, Type 1	Hyper-Igm Immunodeficiency Syndrome, Type 1
Hyperimmunoglobulin M Syndrome

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14038	SUPT5H Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	SUPT5H	VGNC	VGNC:46992
Mus musculus	SUPT5H	MGD	MGI:1202400
Felis catus	SUPT5H	VGNC	VGNC:65849
Macaca mulatta	SUPT5H	VGNC	VGNC:78056
Bos taurus	SUPT5H	VGNC	VGNC:35481
Rattus norvegicus	SUPT5H	RGD	RGD:1563807

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