SUPV3L1 - Suv3 like RNA helicase Gene

中文名称：Suv3 样 RNA 解旋酶

种属: Homo sapiens

同用名: SUV3

基因 ID: 6832 | 基因类型: protein coding

关于 SUPV3L1

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:69,180,234-69,209,093 (from NCBI)

This gene has 7 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in testis (RPKM 11.2), bone marrow (RPKM 8.5) and 25 other tissues.

功能概要

启用解旋酶活性；核酸结合活性；和蛋白质同二聚化活性。参与多个过程，包括线粒体 RNA 代谢过程；线粒体形态发生；线粒体 RNA 分解代谢过程的正调控。位于线粒体的类核和细胞核中。线粒体降解体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables helicase activity; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including mitochondrial RNA metabolic process; mitochondrion morphogenesis; and positive regulation of mitochondrial RNA catabolic process. Located in mitochondrial nucleoid and nucleus. Part of mitochondrial degradosome. [provided by Alliance of Genome Resources, Apr 2022]

SUPV3L1 基因产物(7)

mRNA	Protein	Name
NM_001301683.2	NP_001288612.1	ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 2
NM_001323584.2	NP_001310513.1	ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 2
NM_001323585.2	NP_001310514.1	ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 3
NM_001323586.2	NP_001310515.1	ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 3
NM_001323587.2	NP_001310516.1	ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 4
NM_001323588.2	NP_001310517.1	ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 4
NM_003171.5	NP_003162.2	ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 3'-5' RNA helicase activity	EXP EXP: 通过实验结果推断	15096047	GOA
enables 3'-5' RNA helicase activity	IDA IDA: 通过直接分析推断	19509288	GOA
enables DNA binding	IMP IMP: 通过突变表型推断	12466530	GOA
enables DNA helicase activity	IMP IMP: 通过突变表型推断	12466530	GOA
enables RNA helicase activity	IDA IDA: 通过直接分析推断	19509288	GOA
enables double-stranded RNA binding	IDA IDA: 通过直接分析推断	19509288	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	19509288	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17961633	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	19509288	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA duplex unwinding	IMP IMP: 通过突变表型推断	12466530	GOA
involved in DNA recombination	IMP IMP: 通过突变表型推断	17961633	GOA
involved in RNA catabolic process	IMP IMP: 通过突变表型推断	18678873	GOA
involved in mitochondrial RNA 3'-end processing	IMP IMP: 通过突变表型推断	19864255	GOA
involved in mitochondrial RNA surveillance	IMP IMP: 通过突变表型推断	19864255	GOA
involved in mitochondrial mRNA catabolic process	IMP IMP: 通过突变表型推断	19864255	GOA
involved in mitochondrial mRNA surveillance	IMP IMP: 通过突变表型推断	19864255	GOA
involved in mitochondrial ncRNA surveillance	IMP IMP: 通过突变表型推断	19864255	GOA
involved in mitochondrion organization	IMP IMP: 通过突变表型推断	19864255	GOA
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	17352692	GOA
involved in positive regulation of cell growth	IMP IMP: 通过突变表型推断	19864255	GOA
involved in positive regulation of mitochondrial RNA catabolic process	IDA IDA: 通过直接分析推断	19509288	GOA
involved in positive regulation of mitochondrial RNA catabolic process	IMP IMP: 通过突变表型推断	19864255	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of mitochondrial degradosome	IDA IDA: 通过直接分析推断	19509288	GOA
located in mitochondrial matrix	IDA IDA: 通过直接分析推断	12466530	GOA
located in mitochondrial nucleoid	IDA IDA: 通过直接分析推断	18063578	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	17352692	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17352692	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SUPV3L1 蛋白结构

Helicase_C

SUV3_C

0
200
400
600
786 a.a.

蛋白主名

其他名称

ATP-dependent RNA helicase SUPV3L1, mitochondrial

SUV3-like helicase

SUPV3L1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SUPV3L1	Q8IYB8	PNPT1	Homo sapiens	Q8TCS8	Chromatography	19509288
种属内	SUPV3L1	Q8IYB8	PNPT1	Homo sapiens	Q8TCS8	Anti Tag CoIP	33961781
种属内	SUPV3L1	Q8IYB8	PNPT1	Homo sapiens	Q8TCS8	Anti Tag CoIP	28514442
种属内	SUPV3L1	Q8IYB8	PNPT1	Homo sapiens	Q8TCS8	Solution Sedimentation	19509288
种属内	SUPV3L1	Q8IYB8	PNPT1	Homo sapiens	Q8TCS8	Comig Non-Denat Gel	19509288
种属内	SUPV3L1	Q8IYB8	PNPT1	Homo sapiens	Q8TCS8	SPR	19509288
种属内	SUPV3L1	Q8IYB8	RBM3	Homo sapiens	P98179	Anti Tag CoIP	33961781
种属内	SUPV3L1	Q8IYB8	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
种属内	SUPV3L1	Q8IYB8	RBM3	Homo sapiens	P98179	Anti Tag CoIP	28514442
种属内	SUPV3L1	Q8IYB8	MAGEB6	Homo sapiens	Q8N7X4	Validated Y2H	32296183
种属内	SUPV3L1	Q8IYB8	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
种属内	SUPV3L1	Q8IYB8	MAGEB6	Homo sapiens	Q8N7X4	Y2H Array	32296183
种属内	SUPV3L1	Q8IYB8	SUPV3L1	Homo sapiens	Q8IYB8	Chromatography	19509288
种属内	SUPV3L1	Q8IYB8	SUPV3L1	Homo sapiens	Q8IYB8	Solution Sedimentation	19509288
种属内	SUPV3L1	Q8IYB8	MAGEB6	Homo sapiens	Q8N7X4	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Dyskeratosis Congenita, Autosomal Recessive 5

Dyskeratosis Congenita, Autosomal Dominant, 4	DKCB5
Autosomal Dominant Dyskeratosis Congenita 4	DKCA4
Autosomal Recessive Dyskeratosis Congenita 5	Dyskeratosis Congenita, Autosomal Recessive, 5
Dyskeratosis Congenita, Autosomal Dominant 4	Dyskeratosis Congenita, Autosomal Recessive, Type 5

Neuropathy, Hereditary Motor And Sensory, Russe Type

Charcot-Marie-Tooth Disease Type 4g	HMSNR
Cmt4g	Hereditary Motor And Sensory Neuropathy, Russe Type
Charcot-Marie-Tooth Disease, Type 4g	Charcot-Marie-Tooth Disease, Autosomal Recessive, Type 4g
Charcot-Marie-Tooth Neuropathy Type 4g	Charcot-Marie-Tooth Neuropathy, Type 4g
Autosomal Recessive Charcot-Marie-Tooth Disease Type 4g	Hereditary Motor And Sensory Neuropathy Russe Type
Charcot-Marie-Tooth Disease Autosomal Recessive Type 4g

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Spastic Ataxia

Spax	Ataxia, Spastic

Leigh Syndrome

Leigh Disease	Infantile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency	LS
Sne	Leigh'S Disease
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Necrotizing Encephalopathy, Infantile Subacute, Of Leigh
Subacute Necrotizing Encephalomyelopathy	Necrotizing Encephalopathy Infantile Subacute Of Leigh
Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency	Infantile Necrotizing Encephalomyelopathy
Juvenile Subacute Necrotizing Encephalomyelopathy	Leigh'S Necrotizing Encephalopathy
Subacute Necrotizing Encephalopathy	Juvenile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency	Leigh Syndrome Due To Mitochondrial Complex V Deficiency
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy, Subacute Necrotizing, Juvenile
Maternally Inherited Leigh Syndrome	Subacute Necrotising Encephalomyelopathy
Subacute Necrotising Encephalopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14041	SUPV3L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	SUPV3L1	VGNC	VGNC:46993
Macaca mulatta	SUPV3L1	VGNC	VGNC:106107
Felis catus	SUPV3L1	VGNC	VGNC:65852
Mus musculus	SUPV3L1	MGD	MGI:2441711
Bos taurus	SUPV3L1	VGNC	VGNC:35483
Rattus norvegicus	SUPV3L1	RGD	RGD:1305565

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