TAF10 - TATA-box binding protein associated factor 10 Gene

中文名称：TATA-box 结合蛋白相关因子 10

种属: Homo sapiens

同用名: TAF2A; TAF2H; TAFII30

关于 TAF10

功能概要

RNA 聚合酶 II 启动转录需要 70 多种多肽的活性。协调这些活动的蛋白质是转录因子 IID (TFIID) ，它与核心启动子结合以正确定位聚合酶，充当组装转录复合物其余部分的支架，并充当调节信号的通道。 TFIID 由 TATA 结合蛋白 (TBP) 和一组称为 TBP 相关因子或 TAF 的进化保守蛋白组成。 TAF 可能参与基础转录，充当共激活因子，在启动子识别中发挥作用或修饰一般转录因子 (GTF) 以促进复杂的组装和转录起始。该基因编码与 TFIID 复合物子集相关的 TFIID 小亚基之一。对人类和哺乳动物细胞的研究表明，该亚基是雌激素受体转录激活所必需的，对于细胞周期的进展，也可能是某些细胞分化程序所必需的。[RefSeq 提供，2008 年 7 月]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the Estrogen Receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]