C1QA - complement C1q A chain Gene

中文名称：补充 C1q A 链

种属: Homo sapiens

基因 ID: 712 | 基因类型: protein coding

关于 C1QA

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,636,463-22,639,678 (from NCBI)

This gene has 12 transcripts (splice variants), 171 orthologues, 23 paralogues and is associated with 3 phenotypes. Broad expression in spleen (RPKM 445.5), lymph node (RPKM 179.4) and 16 other tissues.

功能概要

该基因编码血清补体亚组分 C1q 的 A 链多肽，它与 C1r 和 C1s 结合产生血清补体系统的第一个组分。 C1q 缺乏与红斑狼疮和肾小球肾炎有关。 C1q 由 18 条多肽链组成，包括 6 条 A 链、6 条 B 链和 6 条 C 链。每条链包含一个 N 端胶原样区域和一个 C 端 C1q 球状结构域。交替剪接导致多个转录本变体。[RefSeq 提供，2016 年 11 月]

This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum Complement System. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

C1QA 基因产物(3)

mRNA	Protein	Name
NM_001347465.2	NP_001334394.1	complement C1q subcomponent subunit A precursor
NM_001347466.2	NP_001334395.1	complement C1q subcomponent subunit A precursor
NM_015991.4	NP_057075.1	complement C1q subcomponent subunit A precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	7240	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in complement activation, classical pathway	IDA IDA: 通过直接分析推断	29449492	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of complement component C1q complex	IPI IPI: 通过物理相互作用推断	29449492	GOA
located in extracellular region	IDA IDA: 通过直接分析推断	18250442	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

C1QA 蛋白结构

Collagen

C1q

0
100
200
245 a.a.

蛋白主名

其他名称

complement C1q subcomponent subunit A

complement C1q chain A

C1QA 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	C1QA	P02745	Q07021-PRO_0000018590	Homo sapiens	Q07021-PRO_0000018590	Far-WB	28018340
种属内	C1QA	P02745	Q07021-PRO_0000018590	Homo sapiens	Q07021-PRO_0000018590	Solid Phase Assay	34804054
种属内	C1QA	P02745	Q07021-PRO_0000018590	Homo sapiens	Q07021-PRO_0000018590	ELISA	28018340
种属内	C1QA	P02745	C1QB	Homo sapiens	P02746	Affinity Chrom	12960167
种属内	C1QA	P02745	C1QB	Homo sapiens	P02746	X-Ray Diffraction	12960167
种属内	C1QA	P02745	C1QB	Homo sapiens	P02746	ELISA	21054788
种属内	C1QA	P02745	C1QB	Homo sapiens	P02746	Enzymatic Footprint	7240
种属内	C1QA	P02745	C1QB	Homo sapiens	P02746	Filter Binding	28325905
种属内	C1QA	P02745	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
种属内	C1QA	P02745	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
种属内	C1QA	P02745	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
种属内	C1QA	P02745	UBQLN2	Homo sapiens	Q9UHD9	Y2H	21988832
种属内	C1QA	P02745	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
种属内	C1QA	P02745	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
种属内	C1QA	P02745	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

C1QA 抗体

目录号	产品名	应用	反应物种
HY-P81468	C1QA Antibody (YA1213)	IHC-P	Human

关联疾病

疾病名称

别名

C1q Deficiency

C1QD	Complement Component C1q Deficiency

Immunodeficiency Due To A Classical Component Pathway Complement Deficiency

Immunodeficiency Due To C1, C4, Or C2 Component Complement Deficiency

Immunodeficiency Due To An Early Component Of Complement Deficiency

Systemic Lupus Erythematosus 16

SLEB16	Autosomal Systemic Lupus Erythematosus
Autosomal Sle	Familial Sle
Familial Systemic Lupus Erythematosus	Lupus Erythematosus, Systemic, Type 16

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Glomerulonephritis

Bright'S Disease

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Malignant Iris Melanoma

Malignant Melanoma Of Iris

Melanoma Of The Iris

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01718	C1QA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	C1QA	VGNC	VGNC:60219
Canis familiaris	C1QA	VGNC	VGNC:38576
Mus musculus	C1QA	MGD	MGI:88223
Rattus norvegicus	C1QA	RGD	RGD:1306716
Bos taurus	C1QA	VGNC	VGNC:26616
Others	C1QA	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

C1QA - complement C1q A chain Gene

关于 C1QA

功能概要

C1QA 基因产物(3)

C1QA 蛋白结构

C1QA 蛋白互作信息

C1QA 抗体

关联疾病

直系同源

热门区域

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C1QA - complement C1q A chain Gene

关于 C1QA

功能概要

C1QA 基因产物(3)

C1QA 蛋白结构

C1QA 蛋白互作信息

C1QA 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z