TPT1 - tumor protein, translationally-controlled 1 Gene

中文名称：肿瘤蛋白，翻译控制 1

种属: Homo sapiens

同用名: HRF; p02; p23; TCTP

基因 ID: 7178 | 基因类型: protein coding

关于 TPT1

Cytogenetic location: 13q14.13 Genomic coordinates (GRCh38): 13:45,333,471-45,341,183 (from NCBI)

This gene has 14 transcripts (splice variants) and 247 orthologues. Ubiquitous expression in ovary (RPKM 496.6), thyroid (RPKM 416.5) and 25 other tissues.

功能概要

该基因编码的蛋白质是细胞生长和增殖的调节剂。其 mRNA 高度结构化，在其 5' 非翻译区包含寡聚嘧啶束 (5'-TOP) ，在静止条件下起到抑制其翻译的作用。编码的蛋白质参与多种细胞途径，包括细胞凋亡、蛋白质合成和细胞分裂。它结合并稳定微管，通过磷酸化去除这种蛋白质是通过有丝分裂和减数分裂细胞分裂的进展所必需的。已知该基因在致癌作用中起作用，并且在一些癌细胞中被上调。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2017 年 8 月]

This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including Apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some Cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

TPT1 基因产物(3)

mRNA	Protein	Name
NM_001286272.2	NP_001273201.1	translationally-controlled tumor protein isoform 1
NM_001286273.2	NP_001273202.1	translationally-controlled tumor protein isoform 3
NM_003295.4	NP_003286.1	translationally-controlled tumor protein isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium ion binding	IDA IDA: 通过直接分析推断	15162379	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16730713	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: 通过突变表型推断	11598139	GOA
involved in response to virus	IEP IEP: 通过表达模式推断	16548883	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	15162379	GOA
located in cytoplasmic microtubule	IDA IDA: 通过直接分析推断	15162379	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	15319436	GOA
located in multivesicular body	IDA IDA: 通过直接分析推断	15319436	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11598139	GOA
located in spindle pole	IDA IDA: 通过直接分析推断	15162379	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TPT1 蛋白结构

TCTP

0
100
172 a.a.

蛋白主名

其他名称

translationally-controlled tumor protein

fortilin

重组 TPT1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77224	TCTP/TPT1 Protein, Human (His)	P13693 (M1-C172)	≥95%
HY-P700615	TCTP/TPT1 Protein, Human	P13693 (M1-C172)	≥95%
HY-P700623	TCTP/TPT1 Protein, Human (HEK293, His)	P13693 (M1-C172)	≥95%

关联疾病

疾病名称

别名

Chronic Urticaria

Urticaria Chronic	Chronic Spontaneous Urticaria
Chronic Ordinary Urticaria

Drug Allergy

Allergy Drug

Drug Allergies

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Allergic Rhinitis

Hay Fever	Allergic Rhinitis, Susceptibility To
ALRH	Atopic Rhinitis
Seasonal Allergic Rhinitis	Non-Seasonal Allergic Rhinitis
Perenial Allergic Rhinitis	Pollenosis
Rhinitis Allergic Seasonal	Rhinitis, Allergic, Perennial
Allergic Rhinitis, Cause Unspecified	Pollinosis
Pollen Allergy	Allergy Nos Due To Pollen
Summer Catarrh	Other Seasonal Allergic Rhinitis

Rhinitis

Runny Nose

Allergic Disease

Hypersensitivity	Allergic Hypersensitivity Disease
Allergic Condition	Allergic Reaction
Allergic Disposition

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Paraneoplastic Cerebellar Degeneration

Pcd	Paraneoplastic Cerebellar Ataxia
Rapidely Progressive Cerebellar Syndrome	Subacute Cerebellar Degeneration

Mycetoma

Madura Foot

Mycetoma Of Foot

Epithelial-Stromal Tgfbi Dystrophy

Eumycotic Mycetoma

Eumycetoma	Maduromycosis
Mycetoma	Madura Foot
Maduromycosis, Mycotic	Mycotic Mycetoma
Mycetoma Of Foot	Eumycotic Maduromycosis
Mycetoma Due To Fungal Infection

Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria

Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V

Food Allergy

Food Hypersensitivity	Food Allergies
Allergy Food	Food Allergen-Induced Hypersensitivity

Trichothiodystrophy 7, Nonphotosensitive

TTD7	Nonphotosensitive Trichothiodystrophy 7
Trichothiodystrophy 7, Non-Photosensitive

Pericarditis

Diabetic Macular Edema

Dermatomycosis

Dermatomycoses

Retinal Vascular Occlusion

Retinal Vasc. Occlusion	Occlusion Of Retinal Vessels
Retinal Obstruction

Retinal Artery Occlusion

Retina Artery Narrowing	Retinal Artery Spasm
Spasm Of Ophthalmic Artery	Retinal Spasm
Vasospasm Of Retina

Macular Retinal Edema

Macular Edema	Macular Oedema
Macular Retinal Oedema	Macular Edema, Cystoid

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14956	TPT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TPT1	MGD	MGI:104890
Rattus norvegicus	TPT1	RGD	RGD:621623
Felis catus	TPT1	VGNC	VGNC:102352

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TPT1 - tumor protein, translationally-controlled 1 Gene

关于 TPT1

功能概要

TPT1 基因产物(3)

TPT1 蛋白结构

重组 TPT1 蛋白

关联疾病

直系同源

热门区域

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TPT1 - tumor protein, translationally-controlled 1 Gene

关于 TPT1

功能概要

TPT1 基因产物(3)

TPT1 蛋白结构

重组 TPT1 蛋白

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z