UPK2 - uroplakin 2 Gene

中文名称：尿黄素 2

种属: Homo sapiens

同用名: UP2; UPII

基因 ID: 7379 | 基因类型: protein coding

关于 UPK2

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,956,298-118,958,559 (from NCBI)

This gene has 2 transcripts (splice variants) and 100 orthologues. Biased expression in urinary bladder (RPKM 26.3) and fat (RPKM 1.3).

功能概要

该基因编码不对称单元膜的高度保守的尿路上皮特异性整合膜蛋白的一种蛋白质，该膜在哺乳动物中形成尿路上皮顶端斑块。不对称单元膜被认为通过防止膀胱扩张期间的细胞破裂来加强尿路上皮。编码的蛋白质在患有移行细胞癌的膀胱癌患者的外周血中表达。[RefSeq 提供，2009 年 9 月]

This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder Cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]

UPK2 基因产物(1)

mRNA	Protein	Name
NM_006760.4	NP_006751.1	uroplakin-2 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in epithelial cell differentiation	IDA IDA: 通过直接分析推断	10514386	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UPK2 蛋白结构

Uroplakin_II

0
100
184 a.a.

蛋白主名

其他名称

uroplakin-2

uroplakin II

UPK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UPK2	O00526	SMAGP	Homo sapiens	Q0VAQ4	Validated Y2H	32296183
种属内	UPK2	O00526	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
种属内	UPK2	O00526	BSCL2	Homo sapiens	J3KQ12	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32296183
种属内	UPK2	O00526	CLEC17A	Homo sapiens	Q6ZS10	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	CLEC17A	Homo sapiens	Q6ZS10	Y2H Array	32296183
种属内	UPK2	O00526	CLEC17A	Homo sapiens	Q6ZS10	Validated Y2H	32296183
种属内	UPK2	O00526	CLEC7A	Homo sapiens	Q9BXN2-6	Validated Y2H	32296183
种属内	UPK2	O00526	CLEC7A	Homo sapiens	Q9BXN2-6	Y2H Array	32296183
种属内	UPK2	O00526	CLEC7A	Homo sapiens	Q9BXN2-6	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	RNF170	Homo sapiens	Q96K19-5	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	RNF170	Homo sapiens	Q96K19-5	Validated Y2H	32296183
种属内	UPK2	O00526	RNF170	Homo sapiens	Q96K19-5	Y2H Array	32296183
种属内	UPK2	O00526	SLC22A23	Homo sapiens	A1A5C7-2	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	SLC22A23	Homo sapiens	A1A5C7-2	Y2H Array	32296183
种属内	UPK2	O00526	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
种属内	UPK2	O00526	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
种属内	UPK2	O00526	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	PLP1	Homo sapiens	P60201-2	Validated Y2H	32296183
种属内	UPK2	O00526	CD74	Homo sapiens	P04233-2	Validated Y2H	32296183
种属内	UPK2	O00526	CD74	Homo sapiens	P04233-2	Y2H Array	32296183
种属内	UPK2	O00526	CD74	Homo sapiens	P04233-2	Complementation	32296183
种属内	UPK2	O00526	CD74	Homo sapiens	P04233-2	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	TMPRSS2	Homo sapiens	O15393-2	Validated Y2H	32296183
种属内	UPK2	O00526	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
种属内	UPK2	O00526	ASGR2	Homo sapiens	P07307-3	Y2H Array	32296183
种属内	UPK2	O00526	ASGR2	Homo sapiens	P07307-3	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	ASGR2	Homo sapiens	P07307-3	Validated Y2H	32296183
种属内	UPK2	O00526	ITM2C	Homo sapiens	Q9NQX7-3	Validated Y2H	32296183
种属内	UPK2	O00526	ITM2C	Homo sapiens	Q9NQX7-3	Y2H Array	32296183
种属内	UPK2	O00526	HPN	Homo sapiens	P05981	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	HPN	Homo sapiens	P05981	Validated Y2H	32296183
种属内	UPK2	O00526	HPN	Homo sapiens	P05981	Y2H Array	32296183
种属内	UPK2	O00526	STOML3	Homo sapiens	Q8TAV4	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	STOML3	Homo sapiens	Q8TAV4	Validated Y2H	32296183
种属内	UPK2	O00526	STOML3	Homo sapiens	Q8TAV4	Y2H Array	32296183
种属内	UPK2	O00526	FCGR2A	Homo sapiens	P12318-2	Validated Y2H	32296183
种属内	UPK2	O00526	FCGR2A	Homo sapiens	P12318-2	Y2H Array	32296183
种属内	UPK2	O00526	FCGR2A	Homo sapiens	P12318-2	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	KIR3DL3	Homo sapiens	Q8N743	Validated Y2H	32296183
种属内	UPK2	O00526	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
种属内	UPK2	O00526	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	BTNL9	Homo sapiens	Q6UXG8-3	Validated Y2H	32296183
种属内	UPK2	O00526	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Array	32296183
种属内	UPK2	O00526	ADGRG3	Homo sapiens	Q86Y34	Validated Y2H	32296183
种属内	UPK2	O00526	ADGRG3	Homo sapiens	Q86Y34	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	ADGRG3	Homo sapiens	Q86Y34	Y2H Array	32296183
种属内	UPK2	O00526	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
种属内	UPK2	O00526	AMIGO1	Homo sapiens	Q86WK6	Validated Y2H	32296183
种属内	UPK2	O00526	ZNRF4	Homo sapiens	Q8WWF5	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	ZNRF4	Homo sapiens	Q8WWF5	Validated Y2H	32296183
种属内	UPK2	O00526	ZNRF4	Homo sapiens	Q8WWF5	Y2H Array	32296183
种属内	UPK2	O00526	ATP6AP2	Homo sapiens	O75787	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	ATP6AP2	Homo sapiens	O75787	Validated Y2H	32296183
种属内	UPK2	O00526	ATP6AP2	Homo sapiens	O75787	Y2H Array	32296183
种属内	UPK2	O00526	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
种属内	UPK2	O00526	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
种属内	UPK2	O00526	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
种属内	UPK2	O00526	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
种属内	UPK2	O00526	FCGRT	Homo sapiens	P55899	Validated Y2H	32296183
种属内	UPK2	O00526	FCGRT	Homo sapiens	P55899	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	FCGRT	Homo sapiens	P55899	Y2H Array	32296183
种属内	UPK2	O00526	FCGR1A	Homo sapiens	P12314	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	FCGR1A	Homo sapiens	P12314	Y2H Array	32296183
种属内	UPK2	O00526	FCGR1A	Homo sapiens	P12314	Validated Y2H	32296183
种属内	UPK2	O00526	GPA33	Homo sapiens	Q99795	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	GPA33	Homo sapiens	Q99795	Y2H Array	32296183
种属内	UPK2	O00526	GPA33	Homo sapiens	Q99795	Validated Y2H	32296183
种属内	UPK2	O00526	TNFSF14	Homo sapiens	O43557	Validated Y2H	32296183
种属内	UPK2	O00526	TNFSF14	Homo sapiens	O43557	Y2H Array	32296183
种属内	UPK2	O00526	TNFSF14	Homo sapiens	O43557	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	TNFSF11	Homo sapiens	O14788	Validated Y2H	32296183
种属内	UPK2	O00526	TNFSF11	Homo sapiens	O14788	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	TNFSF11	Homo sapiens	O14788	Y2H Array	32296183
种属内	UPK2	O00526	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
种属内	UPK2	O00526	CLDN7	Homo sapiens	O95471	Validated Y2H	32296183
种属内	UPK2	O00526	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	25416956
种属内	UPK2	O00526	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
种属内	UPK2	O00526	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
种属内	UPK2	O00526	KIR2DL3	Homo sapiens	P43628	Validated Y2H	32296183
种属内	UPK2	O00526	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UPK2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71013	UPK2 Protein, Human (HEK293, His)	O00526 (D26-G155)	≥95%

UPK2 抗体

目录号	产品名	应用	反应物种
HY-P81514	Uroplakin II/UPII Antibody (YA1259)	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human

关联疾病

疾病名称

别名

Transitional Cell Carcinoma

Transitional Cell Neoplasm	Carcinoma, Transitional Cell
Transitional Carcinoma	Transitional Cell Tumor
Urothelial Cell Carcinoma	Carcinoma Transitional Cell
Transitional Cell Carcinoma Of Bladder

Bladder Carcinoma In Situ

Carcinoma In Situ Of Bladder	Bladder Ca In Situ
Flat Cis Of The Urinary Bladder	Carcinoma In Situ Of Urinary Bladder

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Male Urethral Cancer

Male Urethral Malignant Neoplasm

Gastric Signet Ring Cell Adenocarcinoma

Signet Ring Cell Gastric Adenocarcinoma

Signet Ring Cell Adenocarcinoma Of The Stomach

Interstitial Cystitis

Bladder Pain Syndrome	Painful Bladder Syndrome
Ulcerative Cystitis	Ic/Bps
Ic/Pbs	Interstitial Cystitis/Bladder Pain Syndrome
Interstitial Cystitis/Painful Bladder Syndrome	Cystitis, Interstitial
Chronic Interstitial Cystitis	Pelvic Congestion Syndrome
Trigonitis

Ovarian Cystic Teratoma

Fraser Syndrome 1

Fraser Syndrome	Cryptophthalmos With Other Malformations
Cryptophthalmos Syndrome	FRASRS1
Cryptophthalmos-Syndactyly Syndrome	Fraser-Francois Syndrome
Cyclopism	Meyer-Schwickerath'S Syndrome
Ulrich-Feichtiger Syndrome	Cryptophthalmos Syndactyly Syndrome
Fraser'S Syndrome	Meyer-Schwickerath Syndrome
Ullrich-Feichtiger Syndrome

Urethral Stricture

Ankylurethria	Urethral Stenosis
Urethral Contracture	Urethral Obstruction
Meatal Stenosis Nos	Constriction Of Urethra
Contraction Of Urethra	Stricture Of Urinary Meatus
Urethral Obliteration	Urethral Narrowing
Pinpoint Meatus	Pinhole Meatus Nos
Urethral Occlusion

Cystitis Cystica

Acute Cystitis

Urinary Tract Infection

Recurrent Urinary Tract Infection

Chronic Cystitis

Mature Teratoma Of The Ovary

Bladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Bladder	Epidermoid Carcinoma Of The Urinary Bladder
Carcinoma Squamous Cell Bladder

Prune Belly Syndrome

Eagle-Barrett Syndrome	Abdominal Muscle Deficiency Syndrome
PBS	Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism
Egbrs	Eagle-Barret Syndrome
Urethral Obstruction Sequence	Obrinsky Syndrome
Triad Syndrome	Obrisnksy Syndrome
Euos	Early Urethral Obstruction Sequence
Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction	Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism
Abdomen Muscle Deficiency Syndrome	Abdomen Muscular Deficiency Syndrome
Abdominal Muscular Deficiency Syndrome	Abdominal Muscle Aplasia Syndrome

Vesicoureteral Reflux

Vesico-Ureteral Reflux

Hydronephrosis

Stricture Of Ureteropelvic Junction With Hydronephrosis

Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15487	UPK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	UPK2	VGNC	VGNC:36686
Felis catus	UPK2	VGNC	VGNC:66844
Rattus norvegicus	UPK2	RGD	RGD:1597393
Macaca mulatta	UPK2	VGNC	VGNC:107662
Canis familiaris	UPK2	VGNC	VGNC:48156
Mus musculus	UPK2	MGD	MGI:98913
Others	UPK2	NCBI

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