VIL1 - villin 1 Gene

中文名称：反派 1

种属: Homo sapiens

同用名: VIL; D2S1471

基因 ID: 7429 | 基因类型: protein coding

关于 VIL1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,419,123-218,453,295 (from NCBI)

This gene has 5 transcripts (splice variants), 166 orthologues and 7 paralogues. Biased expression in small intestine (RPKM 141.0), duodenum (RPKM 126.6) and 3 other tissues.

功能概要

该基因编码钙调节肌动蛋白结合蛋白家族的一个成员。这种蛋白质代表了刷状缘细胞骨架的主要部分，它在肌动蛋白丝的加帽、切断和集束中发挥作用。已观察到 2.7 kb 和 3.5 kb 的两个 mRNA；它们是利用末端外显子中存在的交替聚腺苷酸化信号产生的。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border Cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]

VIL1 基因产物(1)

mRNA	Protein	Name
NM_007127.3	NP_009058.2	villin-1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables actin filament binding	IDA IDA: 通过直接分析推断	11500485	GOA
enables calcium ion binding	IDA IDA: 通过直接分析推断	11500485	GOA
enables calcium ion binding	IMP IMP: 通过突变表型推断	15272027	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17606613	GOA
enables lysophosphatidic acid binding	IDA IDA: 通过直接分析推断	19808673	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: 通过直接分析推断	14594952	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16921170	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	17606613	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in actin filament capping	IDA IDA: 通过直接分析推断	16921170	GOA
involved in actin filament depolymerization	IDA IDA: 通过直接分析推断	11500485	GOA
involved in actin filament polymerization	IDA IDA: 通过直接分析推断	11500485	GOA
involved in actin filament severing	IDA IDA: 通过直接分析推断	16921170	GOA
involved in barbed-end actin filament capping	IMP IMP: 通过突变表型推断	15272027	GOA
involved in cellular response to epidermal growth factor stimulus	IDA IDA: 通过直接分析推断	17229814	GOA
involved in cytoplasmic actin-based contraction involved in cell motility	IDA IDA: 通过直接分析推断	15342783	GOA
involved in epidermal growth factor receptor signaling pathway	IDA IDA: 通过直接分析推断	17229814	GOA
involved in epithelial cell differentiation	IEP IEP: 通过表达模式推断	21492153	GOA
involved in positive regulation of actin filament bundle assembly	IDA IDA: 通过直接分析推断	19808673	GOA
involved in positive regulation of actin filament depolymerization	IMP IMP: 通过突变表型推断	15272027	GOA
involved in positive regulation of cell migration	IDA IDA: 通过直接分析推断	16921170	GOA
involved in positive regulation of epithelial cell migration	IDA IDA: 通过直接分析推断	17229814	GOA
involved in positive regulation of epithelial cell migration	IGI IGI: 通过遗传相互作用推断	18054784	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: 通过突变表型推断	18054784	GOA
involved in positive regulation of lamellipodium morphogenesis	IGI IGI: 通过遗传相互作用推断	18054784	GOA
involved in positive regulation of lamellipodium morphogenesis	IMP IMP: 通过突变表型推断	18054784	GOA
involved in regulation of actin nucleation	IDA IDA: 通过直接分析推断	16921170	GOA
involved in regulation of cell shape	IDA IDA: 通过直接分析推断	16921170	GOA
involved in response to bacterium	IDA IDA: 通过直接分析推断	17182858	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in actin filament bundle	IDA IDA: 通过直接分析推断	17182858	GOA
located in filopodium	IDA IDA: 通过直接分析推断	15342783	GOA
located in lamellipodium	IDA IDA: 通过直接分析推断	16921170	GOA
located in microvillus	IDA IDA: 通过直接分析推断	17182858	GOA
located in ruffle	IDA IDA: 通过直接分析推断	15342783	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VIL1 蛋白结构

Gelsolin

VHP

0
200
400
600
827 a.a.

蛋白主名

其他名称

villin-1

VIL1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	VIL1	P09327	PLCG1	Homo sapiens	P19174	Anti Bait CoIP	17229814
种属内	VIL1	P09327	VIL1	Homo sapiens	P09327	Density Sedimentation	17606613
种属内	VIL1	P09327	VIL1	Homo sapiens	P09327	Crosslink	17606613
种属内	VIL1	P09327	VIL1	Homo sapiens	P09327	GMS	17606613
种属内	VIL1	P09327	TEX11	Homo sapiens	Q8IYF3	Y2H Pooling	16189514
种属内	VIL1	P09327	VIL1	Homo sapiens	P09327	Pull Down	17606613
种属内	VIL1	P09327	VIL1	Homo sapiens	P09327	FRET	17606613
种属内	VIL1	P09327	PLCG1	Homo sapiens	P19174	FRET	17229814

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Contagious Pustular Dermatitis

Ecthyma, Contagious	Orf
Ecthyma Contagiosum	Scabby Mouth
Sheep Pox	Thistle Disease
Contagious Pustular Dermatosis

Milker'S Nodule

Poxviridae Infections	Milker Nodule
Milkers' Node	Paravaccinia
Pseudocowpox	Milker'S Nodes

Liver Disease

Liver Failure	Liver Diseases
Abnormality Of The Liver	Liver Dysfunction
Disorder Of Liver	Hepatic Disorder
Hepatic Disease	Disease Of Bilirubin Metabolism
Disorder Of Bilirubin Metabolism	Liver Decompensation
Liver Function Failure	Hepatic Failure Nos
Liver Failure Nos	End Stage Liver Disease
Decompensated Liver Failure	Decompensation Of Liver Function
Hepatic Decompensation	Hepatic Insufficiency
Liver Cell Necrosis With Hepatic Failure	Liver Insufficiency
Decompensated Liver Disease	End Stage Liver Failure
Liver Necrosis With Hepatic Failure

Spondyloepiphyseal Dysplasia, Nishimura Type

SEDN	Spondyloepiphyseal Dysplasia Nishimura Type

Meckel Diverticulum

Meckel'S Diverticulum

Persistent Vitelline Duct

Chemical Colitis

Colonic Benign Neoplasm

Colon Neoplasm	Colonic Mass
Colonic Tumor	Neoplasm Of Colon
Neoplasm Of The Colon	Colonic Neoplasms
Colon Cancer	Colon Carcinoma Nos
Colonic Cancer	Metastatic Colon Cancer Nos

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15650	VIL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	VIL1	MGD	MGI:98930
Rattus norvegicus	VIL1	RGD	RGD:1307048
Canis familiaris	VIL1	VGNC	VGNC:48261
Macaca mulatta	VIL1	VGNC	VGNC:78768
Felis catus	VIL1	VGNC	VGNC:66942
Bos taurus	VIL1	VGNC	VGNC:36794

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

VIL1 - villin 1 Gene

关于 VIL1

功能概要

VIL1 基因产物(1)

VIL1 蛋白结构

VIL1 蛋白互作信息

关联疾病

直系同源

热门区域

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VIL1 - villin 1 Gene

关于 VIL1

功能概要

VIL1 基因产物(1)

VIL1 蛋白结构

VIL1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z