2. Gene
  3. VRK2 - VRK serine/threonine kinase 2 Gene

VRK2 - VRK serine/threonine kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：VRK 丝氨酸/苏氨酸激酶 2

种属: Homo sapiens

基因 ID: 7444 | 基因类型: protein coding

关于 VRK2

Cytogenetic location: 2p16.1 Genomic coordinates (GRCh38): 2:57,907,592-58,159,920 (from NCBI)

This gene has 10 transcripts (splice variants), 271 orthologues and 12 paralogues. Ubiquitous expression in adrenal (RPKM 6.3), appendix (RPKM 5.7) and 25 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶的牛痘相关激酶 (VRK) 家族成员。编码的蛋白质充当调节细胞凋亡和肿瘤细胞生长的信号通路的效应物。该基因的变异与精神分裂症有关。可变剪接导致在亚细胞定位和生物活性方面存在差异的多种转录本变体。[RefSeq 提供，2014 年 1 月]

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate Apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]

VRK2 基因产物(9)

mRNA Protein Name
NM_001130480.2 NP_001123952.1 serine/threonine-protein kinase VRK2 isoform 1
NM_001130481.2 NP_001123953.1 serine/threonine-protein kinase VRK2 isoform 1
NM_001130482.2 NP_001123954.1 serine/threonine-protein kinase VRK2 isoform 2
NM_001130483.2 NP_001123955.1 serine/threonine-protein kinase VRK2 isoform 3
NM_001288836.1 NP_001275765.1 serine/threonine-protein kinase VRK2 isoform 4
NM_001288837.2 NP_001275766.1 serine/threonine-protein kinase VRK2 isoform 1
NM_001288838.2 NP_001275767.1 serine/threonine-protein kinase VRK2 isoform 3
NM_001288839.2 NP_001275768.1 serine/threonine-protein kinase VRK2 isoform 4
NM_006296.7 NP_006287.2 serine/threonine-protein kinase VRK2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16963744 GOA
enables protein domain specific binding IDA
IDA: 通过直接分析推断
22572157 GOA
enables protein kinase binding IDA
IDA: 通过直接分析推断
22572157 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
14645249 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to oxidative stress IMP
IMP: 通过突变表型推断
17709393 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
14645249 GOA
involved in regulation of MAPK cascade IMP
IMP: 通过突变表型推断
20679487 GOA
involved in regulation of interleukin-1-mediated signaling pathway IMP
IMP: 通过突变表型推断
18286207 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16704422 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
22572157 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
18286207 GOA
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
18286207 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16704422 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
22572157 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VRK2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (30 - 289)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase VRK2

vaccinia related kinase 2

VRK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra VRK2 Q86Y07 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra VRK2 Q86Y07 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra VRK2 Q86Y07 TMEM88 Homo sapiens Q6PEY1
Y2H Prey Pooling
32296183
Intra VRK2 Q86Y07 TMEM88 Homo sapiens Q6PEY1
Y2H Array
32296183
Intra VRK2 Q86Y07 TBXA2R Homo sapiens Q0VAB0
Y2H Array
32296183
Intra VRK2 Q86Y07 TBXA2R Homo sapiens Q0VAB0
Y2H Prey Pooling
32296183
Intra VRK2 Q86Y07 KSR1 Homo sapiens Q8IVT5
Pull Down
20679487
Intra VRK2 Q86Y07 KSR1 Homo sapiens Q8IVT5
Anti Tag CoIP
20679487
Intra VRK2 Q86Y07 KSR1 Homo sapiens Q8IVT5
Confocal
20679487
Intra VRK2 Q86Y07 KSR1 Homo sapiens Q8IVT5
Confocal
22752157
Intra VRK2 Q86Y07 MAP2K1 Homo sapiens Q02750
Pull Down
20679487
Intra VRK2 Q86Y07 MAP2K1 Homo sapiens Q02750
CoIP
20679487
Intra VRK2 Q86Y07 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra VRK2 Q86Y07 MMGT1 Homo sapiens Q8N4V1
Validated Y2H
32296183
Intra VRK2 Q86Y07 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra VRK2 Q86Y07 TMEM205 Homo sapiens Q6UW68
Y2H Prey Pooling
32296183
Intra VRK2 Q86Y07 TMEM205 Homo sapiens Q6UW68
Y2H Array
32296183
Intra VRK2 Q86Y07 GJA5 Homo sapiens P36382
Y2H Array
32296183
Intra VRK2 Q86Y07 GJA5 Homo sapiens P36382
Y2H Prey Pooling
32296183
Intra VRK2 Q86Y07 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra VRK2 Q86Y07 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra VRK2 Q86Y07 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross VRK2 Q86Y07 ear_ebvb9 Epstein-Barr virus P03182
Confocal
16963744
Cross VRK2 Q86Y07 ear_ebvb9 Epstein-Barr virus P03182
Pull Down
16963744
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Vaccinia
Pontocerebellar Hypoplasia, Type 8

Pontocerebellar Hypoplasia Type 8

PCH8

Pontocerebellar Hypoplasia Due To Chmp1a Mutation

Pontocerebellar Hypoplasia 8

Hypoplasia, Pontocerebellar, Type 8
Pontocerebellar Hypoplasia, Type 1a

Pontocerebellar Hypoplasia Type 1a

PCH1A

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pch1

Pontocerebellar Hypoplasia 1a

Hypoplasia, Pontocerebellar, Type 1a

Pontocerebellar Hypoplasia Type 1
Developmental And Epileptic Encephalopathy 94

Epileptic Encephalopathy, Childhood-Onset

Eeoc

DEE94

Childhood Onset Epileptic Encephalopathy

Encephalopathy, Epileptic, Childhood-Onset
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Chromosome 2p16.1-P15 Deletion Syndrome

2p15p16.1 Microdeletion Syndrome

2p15-P16.1 Microdeletion Syndrome

Del(2)(P15p16.1)

Monosomy 2p15p16.1

Monosomy 2p15-P16.1
Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1

PCH1E

Norman Disease

Pch1

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia Type 1e

Pontocerebellar Hypoplasia 1e

Doid:0112322

Doid:0112330
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

Adnfle

Autosomal Dominant Sleep-Related Hypermotor Epilepsy

Enfl

Benign Familial Infantile Seizures 6

Benign Familial Infantile Seizures, 6

Nocturnal Frontal Lobe Epilepsy-4

Enfl1

Epilepsy, Nocturnal Frontal Lobe, 1

Epilepsy, Nocturnal Frontal Lobe, Type 1
Epilepsy, Myoclonic Juvenile

Juvenile Myoclonic Epilepsy

Janz Syndrome

Jme

Myoclonic Epilepsy, Juvenile, Susceptibility To, 1

EJM

Myoclonic Epilepsy, Juvenile

Petit Mal, Impulsive

Myoclonic Epilepsy, Juvenile 1

Myoclonic Epilepsy, Juvenile, 1

Adolescent Myoclonic Epilepsy

Juvenile Myoclonus Epilepsy

Juvenile Myoclonic Epilepsy 1

EJM1

Petit Mal Impulsive

Susceptibility To Juvenile Myoclonic Epilepsy 1

Myoclonic Epilepsy Juvenile

Epilepsy, Myoclonic, Juvenile

Myoclonic Epilepsy Of Janz

Jme - [Juvenile Myoclonic Epilepsy]
Nanophthalmos

Nanophthalmia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N8692 Dihydrobaicalein Inhibitor 99.94% 否
HY-RS15703 VRK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus VRK2 MGD MGI:1917172
Rattus norvegicus VRK2 RGD RGD:1311585
Macaca mulatta VRK2 VGNC VGNC:81604
Felis catus VRK2 VGNC VGNC:83479
Canis familiaris VRK2 VGNC VGNC:48303
Bos taurus VRK2 VGNC VGNC:36835
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