1. Gene
  2. Il33 - interleukin 33 Gene

Il33 - interleukin 33 Gene

种属: Mus musculus

同用名: Il-33; Il1f11; NF-HEV; 9230117N10Rik

基因 ID: 77125 | 基因类型: protein coding

关于 Il33

功能概要

Enables cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; microglial cell activation involved in immune response; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of macrophage proliferation; positive regulation of cellular defense response; and positive regulation of macromolecule metabolic process. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33). [provided by Alliance of Genome Resources, Apr 2022]

Il33 基因产物(3)

mRNA Protein Name
NM_001164724.2 NP_001158196.1 interleukin-33
NM_001360725.1 NP_001347654.1 interleukin-33
NM_133775.3 NP_598536.2 interleukin-33
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine activity IDA
IDA: 通过直接分析推断
19841166 MGI
enables cytokine activity IPI
IPI: 通过物理相互作用推断
17623648 MGI
enables interleukin-33 receptor binding IPI
IPI: 通过物理相互作用推断
29045903 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
29045903 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chemokine production IDA
IDA: 通过直接分析推断
32144162 MGI
involved in cytokine production IDA
IDA: 通过直接分析推断
32144162 MGI
acts upstream of or within defense response to virus IDA
IDA: 通过直接分析推断
23630360 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
22660580 MGI
acts upstream of gene expression IDA
IDA: 通过直接分析推断
19666510 MGI
involved in gene expression IDA
IDA: 通过直接分析推断
32144162 MGI
involved in interleukin-33-mediated signaling pathway IDA
IDA: 通过直接分析推断
26936882 MGI
involved in macrophage activation involved in immune response IDA
IDA: 通过直接分析推断
21494550 MGI
involved in macrophage differentiation IDA
IDA: 通过直接分析推断
34644537 MGI
involved in microglial cell activation involved in immune response IDA
IDA: 通过直接分析推断
21349253 MGI
involved in microglial cell proliferation IDA
IDA: 通过直接分析推断
21349253 MGI
involved in negative regulation of T-helper 1 type immune response IGI
IGI: 通过遗传相互作用推断
18268038 MGI
involved in negative regulation of immunoglobulin production IGI
IGI: 通过遗传相互作用推断
18268038 MGI
involved in negative regulation of inflammatory response to wounding IDA
IDA: 通过直接分析推断
27830702 MGI
involved in negative regulation of leukocyte migration IGI
IGI: 通过遗传相互作用推断
18268038 MGI
acts upstream of or within negative regulation of macrophage proliferation IDA
IDA: 通过直接分析推断
26936882 MGI
involved in negative regulation of type II interferon production IGI
IGI: 通过遗传相互作用推断
18268038 MGI
acts upstream of or within positive regulation of CD80 production IDA
IDA: 通过直接分析推断
26936882 MGI
acts upstream of or within positive regulation of CD86 production IDA
IDA: 通过直接分析推断
26936882 MGI
acts upstream of or within positive regulation of MHC class I biosynthetic process IDA
IDA: 通过直接分析推断
26936882 MGI
acts upstream of or within positive regulation of MHC class II biosynthetic process IDA
IDA: 通过直接分析推断
26936882 MGI
acts upstream of or within positive regulation of cellular defense response IMP
IMP: 通过突变表型推断
26936882 MGI
involved in positive regulation of chemokine production IDA
IDA: 通过直接分析推断
19841166 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: 通过直接分析推断
19666510 MGI
involved in positive regulation of immunoglobulin production IGI
IGI: 通过遗传相互作用推断
18268038 MGI
involved in positive regulation of inflammatory response IDA
IDA: 通过直接分析推断
19841166 MGI
involved in positive regulation of interleukin-13 production IGI
IGI: 通过遗传相互作用推断
18268038 MGI
involved in positive regulation of interleukin-4 production IGI
IGI: 通过遗传相互作用推断
18268038 MGI
involved in positive regulation of interleukin-5 production IGI
IGI: 通过遗传相互作用推断
18268038 MGI
acts upstream of positive regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
26936882 MGI
acts upstream of or within positive regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
26936882 MGI
involved in positive regulation of interleukin-6 production IGI
IGI: 通过遗传相互作用推断
18268038 MGI
acts upstream of or within positive regulation of macrophage activation IDA
IDA: 通过直接分析推断
26936882 MGI
involved in positive regulation of macrophage activation IDA
IDA: 通过直接分析推断
19841166 MGI
acts upstream of or within positive regulation of nitric-oxide synthase biosynthetic process IDA
IDA: 通过直接分析推断
26936882 MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
22660580 MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
IGI: 通过遗传相互作用推断
22660580 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19841166 MGI
acts upstream of positive regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
26936882 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
26936882 MGI
acts upstream of or within positive regulation of type 2 immune response IDA
IDA: 通过直接分析推断
23630360 MGI
involved in positive regulation of type 2 immune response IGI
IGI: 通过遗传相互作用推断
18268038 MGI
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
32144162 MGI
acts upstream of type 2 immune response IDA
IDA: 通过直接分析推断
23630360 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
27830702 MGI
located in nucleus IDA
IDA: 通过直接分析推断
29045903 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

interleukin-33

nuclear factor from high endothelial venules

重组 Il33 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7218 IL-33 Protein, Mouse Q8BVZ5 (S109-I266) ≥95%
HY-P700208AF Animal-Free IL-33 Protein, Mouse (His) Q8BVZ5 (S109-I266) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il33 NCBI NCBI:90865
Macaca fascicularis Il33 NCBI NCBI:102140695
Macaca mulatta Il33 NCBI NCBI:717301