MAP3K12 - mitogen-activated protein kinase kinase kinase 12 Gene

中文名称：丝裂原活化蛋白激酶激酶激酶 12

种属: Homo sapiens

同用名: DLK; MUK; ZPK; ZPKP1; MEKK12; HP09298

关于 MAP3K12

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶家族的成员。该激酶包含一个亮氨酸拉链结构域，主要在神经元细胞中表达。该激酶在突触末端的磷酸化状态显示受神经钙蛋白的膜去极化调节。这种激酶与含有转录因子的亮氨酸拉链形成异二聚体，例如 cAMP 反应元件结合蛋白 (CREB) 和 MYC，因此可能在 PKA 或视黄酸诱导的神经元分化中发挥调节作用。已经描述了编码不同蛋白质的可变剪接转录变体。[RefSeq 提供，2010 年 7 月]

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via Calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]