2. Gene
  3. BTG2 - BTG anti-proliferation factor 2 Gene

BTG2 - BTG anti-proliferation factor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：BTG 抗增殖因子 2

种属: Homo sapiens

同用名: PC3; APRO1; TIS21

基因 ID: 7832 | 基因类型: protein coding

关于 BTG2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:203,305,519-203,309,602 (from NCBI)

This gene has 2 transcripts (splice variants), 158 orthologues, 3 paralogues and is associated with 46 phenotypes. Ubiquitous expression in ovary (RPKM 185.2), esophagus (RPKM 183.2) and 23 other tissues.

功能概要

该基因编码的蛋白质是 BTG/Tob 家族的成员。该家族具有结构相关的蛋白质，这些蛋白质似乎具有抗增殖特性。这种编码的蛋白质参与细胞周期 G1/S 转换的调节。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]

BTG2 基因产物(1)

mRNA Protein Name
NM_006763.3 NP_006754.1 protein BTG2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9712883 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IDA
IDA: 通过直接分析推断
8944033 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
23236473 GOA
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
23236473 GOA
involved in neuron projection development IMP
IMP: 通过突变表型推断
18773938 GOA
acts upstream of or within positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
IDA: 通过直接分析推断
18337750 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BTG2 蛋白结构

BTG

BTG: BTG family (9 - 124)

  • 0
  • 100
  • 158 a.a.
蛋白主名 其他名称

protein BTG2

B-cell translocation gene 2

BTG2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
BTG2 P78543 Cnot7 Mus musculus Q60809
Y2H
18337750
种属间
BTG2 P78543 Cnot7 Mus musculus Q60809
Y2H
9712883
种属内
BTG2 P78543 CNOT7 Homo sapiens Q9UIV1
Y2H Array
32296183
种属内
BTG2 P78543 CNOT7 Homo sapiens Q9UIV1
Pull Down
11136725
种属内
BTG2 P78543 CNOT7 Homo sapiens Q9UIV1
Y2H
11136725
种属内
BTG2 P78543 CNOT7 Homo sapiens Q9UIV1
Y2H Prey Pooling
25416956
种属内
BTG2 P78543 CNOT7 Homo sapiens Q9UIV1
Validated Y2H
25416956
种属内
BTG2 P78543 CNOT7 Homo sapiens Q9UIV1
Y2H Prey Pooling
32296183
种属内
BTG2 P78543 CNOT7 Homo sapiens Q9UIV1
Validated Y2H
32296183
种属内
BTG2 P78543 CNOT7 Homo sapiens Q9UIV1
Y2H Array
25416956
种属内
BTG2 P78543 AR Homo sapiens P10275
Pull Down
21172304
种属内
BTG2 P78543 AR Homo sapiens P10275
Anti Bait CoIP
21172304
种属内
BTG2 P78543 CNOT8 Homo sapiens Q9UFF9
Y2H Prey Pooling
25416956
种属内
BTG2 P78543 CNOT8 Homo sapiens Q9UFF9
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Dlbcl Abc Type
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01663 BTG2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BTG2 VGNC VGNC:70288
Bos taurus BTG2 VGNC VGNC:26598
Rattus norvegicus BTG2 RGD RGD:2225
Felis catus BTG2 VGNC VGNC:107845
Mus musculus BTG2 MGD MGI:108384
Canis familiaris BTG2 VGNC VGNC:54278
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