2. Gene
  3. Cdk19 - cyclin-dependent kinase 19 Gene

Cdk19 - cyclin-dependent kinase 19 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 19

种属: Mus musculus

同用名: CDK11; Cdc2l6; mKIAA1028; 2700084L06Rik

基因 ID: 78334 | 基因类型: protein coding

关于 Cdk19

Chromosome 10: 40,215,560-40,359,814 forward strand.GRCm39:CM001003.3

This gene has 5 transcripts (splice variants), 207 orthologues, 25 paralogues and is associated with 4 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 11.6), cortex adult (RPKM 9.7) and 25 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动 RNA 聚合酶 II CTD 七肽重复激酶活性和细胞周期蛋白依赖性蛋白丝氨酸/苏氨酸激酶活性。预计参与细胞凋亡过程的正向调控；炎症反应的正向调节；和蛋白质磷酸化。预测作用于磷酸化上游或内部。预计位于细胞质中。预计是中介复合体的一部分。预计在胞质溶胶和细胞核中有活性。在内淋巴附属物和耳囊中表达。该基因的人类直向同源基因与发育和癫痫性脑病 87 相关。与人类 CDK19（细胞周期蛋白依赖性激酶 19）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in positive regulation of apoptotic process; positive regulation of inflammatory response; and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm. Predicted to be part of mediator complex. Predicted to be active in cytosol and nucleus. Is expressed in endolymphatic appendage and otocyst. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87. Orthologous to human CDK19 (cyclin dependent kinase 19). [provided by Alliance of Genome Resources, Apr 2022]

Cdk19 基因产物(4)

mRNA Protein Name
NM_001291816.1 NP_001278745.1 cyclin-dependent kinase 19 isoform 3
NM_001291817.1 NP_001278746.1 cyclin-dependent kinase 19 isoform 4
NM_198164.3 NP_937807.2 cyclin-dependent kinase 19 isoform 2
NM_001168304.1 NP_001161776.1 cyclin-dependent kinase 19 isoform 1

Cdk19 蛋白结构

STKc_CDC2L6

STKc_CDC2L6: cd07867 (17 - 334)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 19

CDC2-related protein kinase 6

cell division cycle 2-like 6 (CDK8-like)

cell division cycle 2-like protein kinase 6

cell division protein kinase 19

cyclin-dependent kinase (CDC2-like) 11

cyclin-dependent kinase 11

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-101800 Senexin B Inhibitor 99.72% Phase 1
Pre-clinical Phase
生物活性分子 (15)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126675A AS2863619 Inhibitor 99.94% 否
HY-111388A SEL120-34A monohydrochloride Inhibitor 99.29% 否
HY-19984 CCT-251921 Inhibitor 99.01% 否
HY-15681 Senexin A Inhibitor 99.79% 否
HY-122586 BRD6989 Inhibitor 99.56% 否
HY-111388B SEL120-34A hydrochloride Inhibitor 99.98% 否
HY-139875 JH-XVI-178 Inhibitor 98.16% 否
HY-126675 AS2863619 free base Inhibitor 99.87% 否
HY-143889 Senexin C Inhibitor 98.82% 否
HY-111427 CDK8/19-IN-1 Inhibitor 98.03% 否
HY-111388 SEL120-34A Inhibitor / 否
HY-15681A Senexin A hydrochloride Inhibitor / 否
HY-D2311 CDK19 Probe 1 / 否
HY-168846 CDK8/19-IN-3 Inhibitor / 否
HY-158377 CDK8/19-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdk19 NCBI NCBI:23097
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