TLE6 - TLE family member 6, subcortical maternal complex member Gene

中文名称：TLE 家族成员 6，皮质下母体复合体成员

种属: Homo sapiens

同用名: GRG6; PREMBL

基因 ID: 79816 | 基因类型: protein coding

关于 TLE6

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,977,401-2,995,179 (from NCBI)

This gene has 10 transcripts (splice variants), 83 orthologues, 6 paralogues and is associated with 1 phenotype. Broad expression in thyroid (RPKM 2.5), placenta (RPKM 2.5) and 21 other tissues.

功能概要

该基因编码转录共抑制因子分裂家族的 Groucho/转导蛋白样增强子的成员。编码的蛋白质是哺乳动物皮层下母体复合体的一个组成部分，这是植入前发育所必需的。在小鼠中，敲除该基因会导致卵裂期胚胎停滞，这是由于细胞质 F-肌动蛋白网状结构缺陷和不对称细胞分裂所致。在人类中，该基因的等位基因变异与植入前胚胎致死率有关。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 9 月]

This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

TLE6 基因产物(2)

mRNA	Protein	Name
NM_001143986.2	NP_001137458.1	transducin-like enhancer protein 6 isoform 1
NM_024760.3	NP_079036.1	transducin-like enhancer protein 6 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25542835	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in embryonic process involved in female pregnancy	IMP IMP: 通过突变表型推断	26537248	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	25542835	GOA
part of protein-containing complex	IMP IMP: 通过突变表型推断	26537248	GOA
part of subcortical maternal complex	IDA IDA: 通过直接分析推断	25542835	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

transducin-like enhancer protein 6

transducin like enhancer of split 6

TLE6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TLE6	Q9H808	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
种属内	TLE6	Q9H808	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
种属内	TLE6	Q9H808	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Preimplantation Embryonic Lethality 1

Preimplantation Embryonic Lethality	PREMBL1
Prembl	Lethality, Embryonic, Preimplantation
Lethality, Embryonic, Preimplantation, Type 1

Infertility

Gestational Trophoblastic Neoplasm

Hydatidiform Mole	Molar Pregnancy
Gestational Trophoblastic Neoplasia	Gestational Trophoblastic Tumor
Gtn	Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasms	Hydatidiform Mole, Recurrent, 1
Hydatidiform Mole Benign	Trophoblastic Disease
Trophoblastic Disease Nos	Trophoblastic Disorder
Vesicular Mole Nos	Vesicular Mole
Hydatidiform Mole Nos

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Trophoblastic Neoplasm

Trophoblastic Tumor

Trophoblastic Neoplasms

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14568	TLE6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	TLE6	VGNC	VGNC:79879
Mus musculus	TLE6	MGD	MGI:2149593
Felis catus	TLE6	VGNC	VGNC:80735
Rattus norvegicus	TLE6	RGD	RGD:1561530
Bos taurus	TLE6	VGNC	VGNC:52895

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TLE6 - TLE family member 6, subcortical maternal complex member Gene

关于 TLE6

功能概要

TLE6 基因产物(2)

TLE6 蛋白互作信息

关联疾病

直系同源

热门区域

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TLE6 - TLE family member 6, subcortical maternal complex member Gene

关于 TLE6

功能概要

TLE6 基因产物(2)

TLE6 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z