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  3. TAS1R1 - taste 1 receptor member 1 Gene

TAS1R1 - taste 1 receptor member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：味觉 1 受体成员 1

种属: Homo sapiens

同用名: TR1; T1R1; GM148; GPR70

基因 ID: 80835 | 基因类型: protein coding

关于 TAS1R1

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,555,307-6,579,755 (from NCBI)

This gene has 4 transcripts (splice variants), 111 orthologues and 4 paralogues. Biased expression in testis (RPKM 1.2), gall bladder (RPKM 0.1) and 7 other tissues.

功能概要

该基因编码的蛋白质是 G 蛋白偶联受体，是异二聚体氨基酸味觉受体 T1R1+3 的组成部分。 T1R1+3 受体对 L-氨基酸有反应，但对 D-对映体或其他化合物没有反应。大多数被认为是甜味的氨基酸会激活 T1R1+3，并且这种激活严格依赖于完整的 T1R1+3 异二聚体。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2010 年 6 月]

The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid Taste Receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or Other compounds. Most Amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

TAS1R1 基因产物(2)

mRNA Protein Name
NM_138697.4 NP_619642.2 taste receptor type 1 member 1 isoform b precursor
NM_177540.3 NP_803884.1 taste receptor type 1 member 1 isoform c precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables taste receptor activity IPI
IPI: 通过物理相互作用推断
11917125 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in sensory perception of umami taste IDA
IDA: 通过直接分析推断
11917125 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TAS1R1 蛋白结构

ANF_receptor

ANF_receptor: Receptor family ligand binding region (75 - 456)

NCD3G

NCD3G: Nine Cysteines Domain of family 3 GPCR (493 - 545)

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (577 - 815)

  • 0
  • 200
  • 400
  • 600
  • 841 a.a.
蛋白主名 其他名称

taste receptor type 1 member 1

G-protein coupled receptor 70

关联疾病

疾病名称 别名
Dental Caries

Dental Caries Extending Into Pulp

Dental Caries Of Smooth Surface

Dental Caries Pit And Fissure

Smooth Surface Dental Caries

Dental Decay

Carious Teeth

Dental Cavity

Saprodontia

Teeth Decayed

Tooth Caries

Tooth Decay
Glucocorticoid Deficiency 1

Acth Resistance

Glucocorticoid Deficiency, Due To Acth Unresponsiveness

GCCD1

Familial Glucocorticoid Deficiency 1

Fgd1

Adrenal Unresponsiveness To Acth

Hereditary Unresponsiveness To Adrenocorticotropic Hormone

Isolated Glucocorticoid Deficiency
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1

PKD1

Adpkd

Polycystic Kidney Disease, Adult, Type I

Apkd1

Potter Type Iii Polycystic Kidney Disease

Polycystic Kidney Disease, Adult

Potter Type Iii Polycystic Kidney Disease, Formerly

Polycystic Kidney Disease, Type 1

Adpkd1

Adult Polycystic Kidney Disease Type 1

Autosomal Dominant Polycystic Kidney Disease 1

Pkd-1

Polycystic Kidney Disease Adult

Polycystic Kidney Disease Type I

Polycystic Kidneys

Polycystic Kidney Disease, Adult Type I

Polycystic Kidney Type 1 Autosomal Dominant Disease

Kidney Disease, Polycystic, Type 1

Polycystic Kidney, Autosomal Dominant

Polycystic Kidney, Type 1 Autosomal Dominant Disease

Polycystic Kidney Diseases
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14212 TAS1R1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TAS1R1 VGNC VGNC:35607
Mus musculus TAS1R1 MGD MGI:1927505
Macaca mulatta TAS1R1 VGNC VGNC:78115
Canis familiaris TAS1R1 VGNC VGNC:47112
Felis catus TAS1R1 VGNC VGNC:65958
Rattus norvegicus TAS1R1 RGD RGD:61891
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