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  3. RAB1B - RAB1B, member RAS oncogene family Gene

RAB1B - RAB1B, member RAS oncogene family Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAB1B，RAS 致癌基因家族成员

种属: Homo sapiens

基因 ID: 81876 | 基因类型: protein coding

关于 RAB1B

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,268,639-66,277,492 (from NCBI)

This gene has 2 transcripts (splice variants), 235 orthologues and 68 paralogues. Ubiquitous expression in prostate (RPKM 64.5), fat (RPKM 64.0) and 25 other tissues.

功能概要

RAB 蛋白家族的成员，如 RAB1B，是定位于不同膜结合细胞器的细胞质表面的低分子量单体 GTP 酶。 RAB1B 在早期分泌途径中发挥作用，对内质网 (ER) 和高尔基体之间的囊泡运输至关重要 (Chen 等人，1997 [PubMed 9030196]；Alvarez 等人，2003 [PubMed 12802079]) 。[OMIM 提供, 2009 年 1 月]

Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]

RAB1B 基因产物(1)

mRNA Protein Name
NM_030981.3 NP_112243.1 ras-related protein Rab-1B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP binding IDA
IDA: 通过直接分析推断
20937701 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15796781 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi organization IMP
IMP: 通过突变表型推断
26209634 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
IGI: 通过遗传相互作用推断
21680502 GOA
NOT involved in establishment of endothelial intestinal barrier IMP
IMP: 通过突变表型推断
23885123 GOA
involved in positive regulation of glycoprotein metabolic process IGI
IGI: 通过遗传相互作用推断
21680502 GOA
involved in regulation of autophagosome assembly IMP
IMP: 通过突变表型推断
20545908 GOA
involved in virion assembly IGI
IGI: 通过遗传相互作用推断
21680502 GOA
NOT involved in virion assembly IMP
IMP: 通过突变表型推断
21680502 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in phagophore assembly site membrane IDA
IDA: 通过直接分析推断
20545908 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAB1B 蛋白结构

Ras

Ras: Ras family (10 - 170)

  • 0
  • 100
  • 201 a.a.
蛋白主名 其他名称

ras-related protein Rab-1B

small GTP-binding protein

RAB1B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RAB1B Q9H0U4 OCRL Homo sapiens Q01968
FPS
21378754
种属内
RAB1B Q9H0U4 RABIF Homo sapiens P47224
Anti Tag CoIP
28514442
种属内
RAB1B Q9H0U4 RABIF Homo sapiens P47224
Y2H Prey Pooling
32296183
种属内
RAB1B Q9H0U4 RABIF Homo sapiens P47224
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 RAB1B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75993 RAB1B Protein, Human (HEK293, Fc) Q9H0U4 (M1-G199) ≥95%

关联疾病

疾病名称 别名
Hypotrichosis 3

HYPT3

Hypotrichosis Simplex Of The Scalp 2

Htss2

Hypotrichosis, Type 3
Legionnaire Disease

Legionnaires' Disease

Legionnaires Disease

Legionnaire Disease, Susceptibility To

Legionella

Legionella Pneumonia

Infection By Legionella Pneumophilia

Legionnaire'S Disease

Legionellosis

Legionaire Disease, Susceptibility To

Legionnaires Pneumonia
Legionellosis

Legionella Infection

Pontiac Fever

Legionnaires' Disease

Infection By Legionella Pneumophilia

Legionella Pneumophila Infection
Pontiac Fever
Septicemic Plague

Plague, Septicemic
Immunodeficiency 54

Natural Killer Cell Deficiency, Familial Isolated

Primary Immunodeficiency With Natural-Killer Cell Deficiency And Adrenal Insufficiency

IMD54

Nkcd

Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect

Nkgcd

Familial Isolated Natural Killer Cell Deficiency

Primary Immunodeficiency Due To Mcm4 Deficiency
Warburg Micro Syndrome 1

Warburg Micro Syndrome

Micro Syndrome

Warbm

WARBM1

Warburg Sjo Fledelius Syndrome

Warburg-Sjo-Fledelius Syndrome

Micro Syndrome 1

Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11529 RAB1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus RAB1B VGNC VGNC:56276
Rattus norvegicus RAB1B RGD RGD:1642882
Mus musculus RAB1B MGD MGI:1923558
Canis familiaris RAB1B VGNC VGNC:52037
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