BRAP - BRCA1 associated protein Gene

中文名称：BRCA1 相关蛋白

种属: Homo sapiens

同用名: IMP; BRAP2; RNF52

基因 ID: 8315 | 基因类型: protein coding

关于 BRAP

Cytogenetic location: 12q24.12 Genomic coordinates (GRCh38): 12:111,642,146-111,685,956 (from NCBI)

This gene has 3 transcripts (splice variants) and 206 orthologues. Broad expression in testis (RPKM 24.8), bone marrow (RPKM 8.8) and 24 other tissues.

功能概要

由该基因编码的蛋白质通过其与 BRCA1 和其他蛋白质的核定位信号结合的能力得到鉴定。它是一种细胞质蛋白，可通过在细胞质中保留具有核定位信号的蛋白质来调节核靶向。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and Other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]

BRAP 基因产物(1)

mRNA	Protein	Name
NM_006768.5	NP_006759.3	BRCA1-associated protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	14724641	GOA
enables nuclear localization sequence binding	IDA IDA: 通过直接分析推断	9497340	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9497340	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	14724641	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	14724641	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within MAPK cascade	IDA IDA: 通过直接分析推断	14724641	GOA
acts upstream of or within Ras protein signal transduction	IDA IDA: 通过直接分析推断	14724641	GOA
involved in negative regulation of signal transduction	IDA IDA: 通过直接分析推断	14724641	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	14724641	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	9497340	GOA
part of ubiquitin ligase complex	IDA IDA: 通过直接分析推断	14724641	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BRAP 蛋白结构

BRAP2

zf-RING_2

zf-UBP

0
100
200
300
400
500
592 a.a.

蛋白主名

其他名称

BRCA1-associated protein

RING finger protein 52

BRAP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BRAP	Q7Z569	YJU2	Homo sapiens	Q9BW85	Validated Y2H	32296183
种属内	BRAP	Q7Z569	HRAS	Homo sapiens	P01112	CoIP	14724641
种属内	BRAP	Q7Z569	BRAP	Homo sapiens	Q7Z569	CoIP	14724641
种属内	BRAP	Q7Z569	BRCA1	Homo sapiens	P38398	Pull Down	9497340
种属内	BRAP	Q7Z569	PHLPP1	Homo sapiens	O60346	Y2H	25820252
种属内	BRAP	Q7Z569	HRAS	Homo sapiens	P01112	Pull Down	14724641
种属内	BRAP	Q7Z569	EFHC1	Homo sapiens	Q5JVL4	Y2H	25820252
种属内	BRAP	Q7Z569	AKAP3	Homo sapiens	O75969	Anti Tag CoIP	25820252
种属内	BRAP	Q7Z569	KSR1	Homo sapiens	Q8IVT5	CoIP	14724641
种属内	BRAP	Q7Z569	AKAP3	Homo sapiens	O75969	Y2H	25820252
种属内	BRAP	Q7Z569	Dnmt1	Mus musculus	P13864	Anti Tag CoIP	25820252
种属内	BRAP	Q7Z569	BRAP	Homo sapiens	Q7Z569	Y2H	25820252

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Astereognosia

Somatosensory Agnosia

Tactile Agnosia

Melanoma, Uveal

Uveal Melanoma	Choroidal Melanoma
Melanoma Of Uvea	Iris Melanoma
Malignant Melanoma Of Choroid	Malignant Melanoma Of Iris

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01591	BRAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	BRAP	RGD	RGD:1586551
Bos taurus	BRAP	VGNC	VGNC:26552
Mus musculus	BRAP	MGD	MGI:1919649
Canis familiaris	BRAP	VGNC	VGNC:38515
Felis catus	BRAP	VGNC	VGNC:60163
Macaca mulatta	BRAP	VGNC	VGNC:70278
Others	BRAP	NCBI

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