2. Gene
  3. SETDB2 - SET domain bifurcated histone lysine methyltransferase 2 Gene

SETDB2 - SET domain bifurcated histone lysine methyltransferase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：SET 域分叉组蛋白赖氨酸甲基转移酶 2

种属: Homo sapiens

同用名: CLLD8; CLLL8; KMT1F; C13orf4

基因 ID: 83852 | 基因类型: protein coding

关于 SETDB2

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:49,444,274-49,495,003 (from NCBI)

This gene has 4 transcripts (splice variants), 219 orthologues and 19 paralogues. Ubiquitous expression in testis (RPKM 6.5), lymph node (RPKM 5.5) and 25 other tissues.

功能概要

该基因编码一个蛋白质家族的成员，该家族包含一个甲基 CpG 结合域 (MBD) 和一个 SET 域，并作为组蛋白甲基转移酶发挥作用。这种蛋白质被募集到异染色质中，并在染色体分离的调节中发挥作用。该区域通常在慢性淋巴细胞白血病中缺失。从该基因到下游 PHF11 (PHD 指蛋白 11) 基因发生自然发生的通读转录。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 3 月]

This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

SETDB2 基因产物(9)

mRNA Protein Name
NM_001160308.3 NP_001153780.1 histone-lysine N-methyltransferase SETDB2 isoform b
NM_001320699.2 NP_001307628.1 histone-lysine N-methyltransferase SETDB2 isoform c
NM_001393975.1 NP_001380904.1 histone-lysine N-methyltransferase SETDB2 isoform d
NM_001393976.1 NP_001380905.1 histone-lysine N-methyltransferase SETDB2 isoform e
NM_001393977.1 NP_001380906.1 histone-lysine N-methyltransferase SETDB2 isoform f
NM_001393978.1 NP_001380907.1 histone-lysine N-methyltransferase SETDB2 isoform g
NM_001393979.1 NP_001380908.1 histone-lysine N-methyltransferase SETDB2 isoform h
NM_001393980.1 NP_001380909.1 histone-lysine N-methyltransferase SETDB2 isoform i
NM_031915.3 NP_114121.2 histone-lysine N-methyltransferase SETDB2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone H3K9 methyltransferase activity IDA
IDA: 通过直接分析推断
20404330 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromosome segregation IMP
IMP: 通过突变表型推断
20404330 GOA
involved in mitotic cell cycle IMP
IMP: 通过突变表型推断
20404330 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
20404330 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SETDB2 蛋白结构

MBD

MBD: Methyl-CpG binding domain (152 - 216)

Pre-SET

Pre-SET: Pre-SET motif (233 - 347)

SET

SET: SET domain (366 - 682)

  • 0
  • 200
  • 400
  • 600
  • 707 a.a.
蛋白主名 其他名称

histone-lysine N-methyltransferase SETDB2

SET domain bifurcated 2

SETDB2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SETDB2 Q96T68 ARL14EP Homo sapiens Q8N8R7
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12749 SETDB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SETDB2 MGD MGI:2685139
Rattus norvegicus SETDB2 RGD RGD:2319564
Canis familiaris SETDB2 VGNC VGNC:46061
Macaca mulatta SETDB2 VGNC VGNC:77282
Bos taurus SETDB2 VGNC VGNC:34500
Felis catus SETDB2 VGNC VGNC:108502
Others SETDB2 NCBI
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