1. Gene
  2. USP42 - ubiquitin specific peptidase 42 Gene

USP42 - ubiquitin specific peptidase 42 Gene

中文名称:泛素特异性肽酶 42

种属: Homo sapiens

基因 ID: 84132 | 基因类型: protein coding

关于 USP42

This gene has 7 transcripts (splice variants), 255 orthologues and 71 paralogues. Broad expression in testis (RPKM 9.2), bone marrow (RPKM 4.1) and 24 other tissues.

功能概要

启用硫醇依赖性去泛素化酶。参与蛋白质去泛素化。预测位于核质中。预计在胞质溶胶和细胞核中有活性。 [由基因组资源联盟提供,2022 年 4 月]

Enables thiol-dependent Deubiquitinase. Involved in protein deubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP42 基因产物(3)

mRNA Protein Name
NM_001365764.1 NP_001352693.1 ubiquitin carboxyl-terminal hydrolase 42 isoform 1
NM_001389650.1 NP_001376579.1 ubiquitin carboxyl-terminal hydrolase 42 isoform 3
NM_032172.3 NP_115548.1 ubiquitin carboxyl-terminal hydrolase 42 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
14715245 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22085928 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

USP42 蛋白结构

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (111 - 409)

  • 0
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  • 1316 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 42

deubiquitinating enzyme 42

关联疾病

疾病名称 别名
Deafness, Autosomal Dominant 21

DFNA21

Autosomal Dominant Nonsyndromic Deafness 21

Autosomal Dominant Deafness 21

Deafness, Autosomal Dominant, 21

Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus USP42 VGNC VGNC:50065
Macaca mulatta USP42 VGNC VGNC:79225
Canis familiaris USP42 VGNC VGNC:54087
Mus musculus USP42 MGD MGI:1924050
Rattus norvegicus USP42 RGD RGD:1305231
Felis catus USP42 VGNC VGNC:107828