1. Gene
  2. MED10 - mediator complex subunit 10 Gene

MED10 - mediator complex subunit 10 Gene

中文名称:介体复合物亚基 10

种属: Homo sapiens

同用名: L6; NUT2; TRG20

基因 ID: 84246 | 基因类型: protein coding

关于 MED10

Cytogenetic location: 5p15.31 Genomic coordinates (GRCh38): 5:6,371,874-6,378,547 (from NCBI)

This gene has 3 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in bone marrow (RPKM 22.5), lymph node (RPKM 18.2) and 25 other tissues.

功能概要

MED10 是 Mediator 复合体的一个组成部分,它是通过 RNA 聚合酶 II 激活转录的 DNA 结合因子的共激活因子 (Sato 等人,2003 [PubMed 12584197]) 。[OMIM 提供,2008 年 10 月]

MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

MED10 基因产物(1)

mRNA Protein Name
NM_032286.3 NP_115662.2 mediator of RNA polymerase II transcription subunit 10

MED10 蛋白结构

Med10

Med10: Transcription factor subunit Med10 of Mediator complex (9 - 127)

  • 0
  • 100
  • 135 a.a.
蛋白主名 其他名称

mediator of RNA polymerase II transcription subunit 10

TRG-17

MED10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MED10 Q9BTT4 ARHGDIG Homo sapiens Q99819
Y2H Array
32296183
种属内
MED10 Q9BTT4 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
种属内
MED10 Q9BTT4 TRIM45 Homo sapiens Q9H8W5-2
Validated Y2H
32296183
种属内
MED10 Q9BTT4 MED7 Homo sapiens O43513
Anti Tag CoIP
24882805
种属内
MED10 Q9BTT4 MED7 Homo sapiens O43513
Anti Tag CoIP
33961781
种属内
MED10 Q9BTT4 MED7 Homo sapiens O43513
Anti Tag CoIP
15175163
种属内
MED10 Q9BTT4 MED7 Homo sapiens O43513
Ion Exchange Chrom
15175163
种属内
MED10 Q9BTT4 MED7 Homo sapiens O43513
EM
24882805
种属内
MED10 Q9BTT4 MED7 Homo sapiens O43513
Anti Tag CoIP
35271311
种属内
MED10 Q9BTT4 MED7 Homo sapiens O43513
Anti Tag CoIP
14576168
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cri-Du-Chat Syndrome

5p Deletion Syndrome

5p Partial Monosomy Syndrome

Monosomy 5p

Cat Cry Syndrome

Chromosome 5p Deletion Syndrome

Cri Du Chat Syndrome

5p- Syndrome

5p Minus Syndrome

Chromosome 5p- Syndrome

Chromosome 5 Short Arm Deletion Syndrome

Chromosome 5p Deletion

Deletion 5p

Cri Du Chat

5p Partial Deletion Syndrome

Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Intellectual Developmental Disorder, Autosomal Dominant 48

Mental Retardation, Autosomal Dominant 48

MRD48

Autosomal Dominant Mental Retardation 48

Autosomal Dominant Intellectual Developmental Disorder 48

Junctional Epidermolysis Bullosa

Epidermolysis Bullosa, Junctional

Jeb

Epidermolysis Bullosa Atrophicans

Congenital Junctional Epidermolysis Bullosa

Epidermolysis Bullosa Junctional

Junctional Eb - [Epidermolysis Bullosa]

Jeb - [Junctional Epidermolysis Bullosa]

Lucidolytic Epidermolysis Bullosa

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MED10 RGD RGD:1310128
Mus musculus MED10 MGD MGI:106331
Macaca mulatta MED10 VGNC VGNC:110451
Bos taurus MED10 VGNC VGNC:31347
Canis familiaris MED10 VGNC VGNC:43118
Others MED10 NCBI