2. Gene
  3. Fgfr3 - fibroblast growth factor receptor 3 Gene

Fgfr3 - fibroblast growth factor receptor 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：成纤维细胞生长因子受体 3

种属: Rattus norvegicus

基因 ID: 84489 | 基因类型: protein coding

关于 Fgfr3

Primary_assembly 14: 76,987,993-77,003,341 reverse strand.mRatBN7.2:CM026987.1

This gene has 3 transcripts (splice variants), 191 orthologues, 54 paralogues and is associated with 74 phenotypes. Biased expression in Lung (RPKM 455.3), Brain (RPKM 133.8) and 5 other tissues.

功能概要

该基因编码的蛋白可启动成纤维细胞生长因子结合活性和成纤维细胞生长因子激活受体活性。参与细胞间信号传递；成纤维细胞生长因子受体信号通路；和细胞群增殖的正调节。位于细胞表面；细胞质；和核。软骨肉瘤的生物标志物。该基因的人类直系同源基因与多种疾病有关，包括 Crouzon 综合征-黑棘皮病综合征； LADD 综合症；萨丹；骨发育疾病（多发）；和癌（多发性）。与人 FGFR3（成纤维细胞生长因子受体 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Fibroblast Growth Factor binding activity and fibroblast growth factor-activated receptor activity. Involved in cell-cell signaling; Fibroblast Growth Factor receptor signaling pathway; and positive regulation of cell population proliferation. Located in cell surface; cytoplasm; and nucleus. Biomarker of chondrosarcoma. Human ortholog(s) of this gene implicated in several diseases, including Crouzon syndrome-acanthosis nigricans syndrome; LADD syndrome; SADDAN; bone development disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (Fibroblast Growth Factor receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr3 基因产物(1)

mRNA Protein Name
NM_053429.2 NP_445881.2 fibroblast growth factor receptor 3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fibroblast growth factor binding IPI
IPI: 通过物理相互作用推断
15231666 RGD
enables fibroblast growth factor receptor activity IDA
IDA: 通过直接分析推断
15231666 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell-cell signaling IDA
IDA: 通过直接分析推断
15231666 RGD
involved in fibroblast growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
15231666 RGD
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15231666 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
15614790 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Fgfr3 蛋白结构

Ig_3

Ig_3: pfam13927 (41 - 107)

Ig

Ig: cd00096 (54 - 58)

Ig

Ig: cd00096 (68 - 72)

Ig

Ig: cd00096 (90 - 93)

Ig

Ig: cd00096 (103 - 107)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (144 - 238)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (144 - 147)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (155 - 160)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (164 - 172)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (178 - 183)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (186 - 188)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (197 - 200)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (204 - 209)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (218 - 225)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (228 - 238)

IgI_3_FGFR

IgI_3_FGFR: cd04974 (246 - 249)

IgI_3_FGFR

IgI_3_FGFR: cd04974 (246 - 346)

IgI_3_FGFR

IgI_3_FGFR: cd04974 (253 - 257)

IgI_3_FGFR

IgI_3_FGFR: cd04974 (265 - 272)

IgI_3_FGFR

IgI_3_FGFR: cd04974 (276 - 283)

IgI_3_FGFR

IgI_3_FGFR: cd04974 (298 - 303)

IgI_3_FGFR

IgI_3_FGFR: cd04974 (314 - 319)

IgI_3_FGFR

IgI_3_FGFR: cd04974 (327 - 335)

IgI_3_FGFR

IgI_3_FGFR: cd04974 (338 - 346)

PTKc_FGFR3

PTKc_FGFR3: cd05100 (456 - 789)

  • 0
  • 200
  • 400
  • 600
  • 804 a.a.
蛋白主名 其他名称

fibroblast growth factor receptor 3

相关产品

Approval
生物活性分子 (9)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10981 Lenvatinib Inhibitor 99.75% 是
HY-50904 Nintedanib Inhibitor 99.94% 是
HY-18708 Erdafitinib Inhibitor 99.66% 否
HY-13311 Infigratinib Inhibitor 99.72% 是
HY-109099 Pemigatinib Inhibitor 99.84% 是
HY-100818 Futibatinib Inhibitor 99.65% 否
HY-11106 Nintedanib esylate Inhibitor 99.96% 是
HY-10981A Lenvatinib mesylate Inhibitor 99.86% 是
HY-13311A Infigratinib phosphate Inhibitor 99.74% 是
Clinical Phase
生物活性分子 (15)
目录号 产品名 作用方式
纯度 Phase
HY-13330 Fexagratinib Inhibitor 99.85% Phase 3
HY-50905 Dovitinib Inhibitor 99.88% Phase 3
HY-100019 Rogaratinib Inhibitor 99.86% Phase 3
HY-10207 Dovitinib lactate Inhibitor 99.75% Phase 3
HY-B0062 Dovitinib lactate hydrate Inhibitor / Phase 3
HY-101568 Roblitinib Inhibitor 99.74% Phase 2
HY-13034 Gandotinib Inhibitor 99.58% Phase 2
HY-19981 Derazantinib Inhibitor 99.28% Phase 2
HY-19957 Zoligratinib Inhibitor 99.76% Phase 2
HY-159642 TYRA-300 Inhibitor / Phase 2
HY-101466A E7090 succinate Inhibitor 99.17% Phase 2
HY-13304 LY2874455 Inhibitor 98.03% Phase 1
HY-101768 PRN1371 Inhibitor 99.43% Phase 1
HY-119367 ODM-203 Inhibitor 99.91% Phase 1
HY-19983 ASP5878 Inhibitor 99.69% Phase 1
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99384 Vofatamab Inhibitor 95.00% Phase 2
HY-P99823 Recifercept 97.10% Phase 2
Pre-clinical Phase
生物活性分子 (32)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12823 BLU9931 Inhibitor 99.97% 否
HY-10032 PF 477736 Inhibitor 99.21% 否
HY-18602 FIIN-2 Inhibitor 99.32% 否
HY-15599 SSR128129E Inhibitor 99.85% 否
HY-148779 FGFR3-IN-5 Inhibitor 99.28% 否
HY-145231 FGFR2-IN-2 Inhibitor 98.25% 否
HY-101466 E7090 Inhibitor 99.64% 否
HY-100491 H3B-6527 Inhibitor ≥98.0% 否
HY-131908 CPL304110 Inhibitor 99.85% 否
HY-P3695 VSPPLTLGQLLS Inhibitor 98.81% 否
HY-15813 FIIN-1 Inhibitor 99.11% 否
HY-18603 FIIN-3 Inhibitor 99.66% 否
HY-12965 S49076 Inhibitor 99.44% 否
HY-108933 JK-P3 Inhibitor 99.72% 否
HY-P3695A VSPPLTLGQLLS TFA Inhibitor / 否
HY-142921 FGFR-IN-2 Inhibitor / 否
HY-147714 FGFR3-IN-2 Inhibitor / 否
HY-152146 HDAC-IN-50 Inhibitor / 否
HY-152104 FGFR-IN-9 Inhibitor / 否
HY-156790 FGFR3-IN-6 Inhibitor / 否
HY-148778 FGFR3-IN-4 Inhibitor / 否
HY-156791 FGFR3-IN-7 Inhibitor / 否
HY-147715 FGFR3-IN-3 Inhibitor / 否
HY-150652 FGFR-IN-8 Inhibitor / 否
HY-158248 FGFR4-IN-19 Inhibitor / 否
HY-147713 FGFR3-IN-1 Inhibitor / 否
HY-155028 FGFR-IN-11 Inhibitor / 否
HY-151903S FGFR2/3-IN-1 Inhibitor / 否
HY-164459 AZ8010 Inhibitor / 否
HY-159642G TYRA-300 (GMP) Inhibitor / 否
HY-159503A Segigratinib hydrochloride Inhibitor / 否
HY-15599A SSR128129E free acid Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fgfr3 NCBI NCBI:2261
Mus musculus Fgfr3 NCBI NCBI:14184
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