2. Gene
  3. MAP1LC3A - microtubule associated protein 1 light chain 3 alpha Gene

MAP1LC3A - microtubule associated protein 1 light chain 3 alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：微管相关蛋白 1 轻链 3 α

种属: Homo sapiens

同用名: LC3; LC3A; ATG8E; MAP1ALC3; MAP1BLC3

基因 ID: 84557 | 基因类型: protein coding

关于 MAP1LC3A

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,546,844-34,560,345 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 31.2), fat (RPKM 18.3) and 25 other tissues.

功能概要

MAP1A 和 MAP1B 是微管相关蛋白，可介导微管与细胞骨架成分之间的物理相互作用。 MAP1A 和 MAP1B 分别由一个重链亚基和多个轻链亚基组成。该基因编码的蛋白质是轻链亚基之一，可以与 MAP1A 或 MAP1B 结合。已发现该基因的两个转录本变体编码不同的亚型。变体 1 的表达在许多肿瘤细胞系中受到抑制，表明它可能参与致癌作用。[RefSeq 提供，2012 年 2 月]

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the Cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]

MAP1LC3A 基因产物(2)

mRNA Protein Name
NM_032514.4 NP_115903.1 microtubule-associated proteins 1A/1B light chain 3A isoform a
NM_181509.3 NP_852610.1 microtubule-associated proteins 1A/1B light chain 3A isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phospholipid binding IDA
IDA: 通过直接分析推断
15187094 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11096062 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
25127057 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in autophagosome assembly IMP
IMP: 通过突变表型推断
24290141 GOA
involved in autophagosome maturation IDA
IDA: 通过直接分析推断
28223137 GOA
acts upstream of or within autophagy of mitochondrion IGI
IGI: 通过遗传相互作用推断
22267086 GOA
involved in cellular response to starvation IDA
IDA: 通过直接分析推断
28223137 GOA
involved in macroautophagy IDA
IDA: 通过直接分析推断
28223137 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in autolysosome IDA
IDA: 通过直接分析推断
25327288 GOA
located in autophagosome IDA
IDA: 通过直接分析推断
12740394 GOA
located in cytosol IDA
IDA: 通过直接分析推断
15187094 GOA
located in organelle membrane IDA
IDA: 通过直接分析推断
12740394 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP1LC3A 蛋白结构

Atg8

Atg8: Autophagy protein Atg8 ubiquitin like (16 - 120)

  • 0
  • 100
  • 121 a.a.
蛋白主名 其他名称

microtubule-associated proteins 1A/1B light chain 3A

MAP1 light chain 3-like protein 1

MAP1LC3A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAP1LC3A Q9H492 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
种属内
MAP1LC3A Q9H492 RETREG3 Homo sapiens Q86VR2
Y2H Array
29892012
种属内
MAP1LC3A Q9H492 RETREG3 Homo sapiens Q86VR2
Validated Y2H
25416956
种属内
MAP1LC3A Q9H492 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
种属内
MAP1LC3A Q9H492 RETREG3 Homo sapiens Q86VR2
Y2H Array
25416956
种属内
MAP1LC3A Q9H492 NEK9 Homo sapiens Q8TD19
Phage Display
35044719
种属内
MAP1LC3A Q9H492 NEK9 Homo sapiens Q8TD19
Anti Tag CoIP
20562859
种属内
MAP1LC3A Q9H492 IRGQ Homo sapiens Q8WZA9
BioID
34524948
种属内
MAP1LC3A Q9H492 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
种属内
MAP1LC3A Q9H492 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
种属间
MAP1LC3A Q9H492 Bnip3l Mus musculus Q9Z2F7
ITC
20010802
种属间
MAP1LC3A Q9H492 Bnip3l Mus musculus Q9Z2F7
NMR
20010802
种属间
MAP1LC3A Q9H492 Bnip3l Mus musculus Q9Z2F7
Pull Down
20010802
种属内
MAP1LC3A Q9H492 KRT1 Homo sapiens P04264
FPS
39009827
种属内
MAP1LC3A Q9H492 KRT1 Homo sapiens P04264
Anti Tag CoIP
20562859
种属内
MAP1LC3A Q9H492 FUNDC1 Homo sapiens Q8IVP5
Anti Tag CoIP
20562859
种属内
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
Phage Display
37219487
种属内
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
Phage Display
35044719
种属内
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
20562859
种属内
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
FPS
37219487
种属内
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
Pull Down
23459205
种属内
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
Y2H Array
32296183
种属内
MAP1LC3A Q9H492 SQSTM1 Homo sapiens Q13501
Y2H Prey Pooling
32296183
种属内
MAP1LC3A Q9H492 TBK1 Homo sapiens Q9UHD2
FPS
37219487
种属内
MAP1LC3A Q9H492 TBK1 Homo sapiens Q9UHD2
ITC
37219487
种属内
MAP1LC3A Q9H492 IRS4 Homo sapiens O14654
Phage Display
35044719
种属内
MAP1LC3A Q9H492 IRS4 Homo sapiens O14654
Anti Tag CoIP
20562859
种属内
MAP1LC3A Q9H492 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
种属内
MAP1LC3A Q9H492 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
种属内
MAP1LC3A Q9H492 TNIP1 Homo sapiens Q15025
Y2H Array
31515488
种属内
MAP1LC3A Q9H492 TNIP1 Homo sapiens Q15025
Validated Y2H
25416956
种属内
MAP1LC3A Q9H492 UBQLN4 Homo sapiens Q9NRR5
Confocal
23459205
种属内
MAP1LC3A Q9H492 UBQLN4 Homo sapiens Q9NRR5
Pull Down
23459205
种属内
MAP1LC3A Q9H492 ATG4B Homo sapiens Q9Y4P1
Y2H Array
32296183
种属内
MAP1LC3A Q9H492 ATG4B Homo sapiens Q9Y4P1
Anti Tag CoIP
20562859
种属内
MAP1LC3A Q9H492 ATG4B Homo sapiens Q9Y4P1
Y2H Prey Pooling
32296183
种属内
MAP1LC3A Q9H492 ATG4B Homo sapiens Q9Y4P1
Validated Y2H
32296183
种属内
MAP1LC3A Q9H492 KXD1 Homo sapiens Q9BQD3
Validated Y2H
25416956
种属内
MAP1LC3A Q9H492 KXD1 Homo sapiens Q9BQD3
Y2H Array
32296183
种属内
MAP1LC3A Q9H492 KXD1 Homo sapiens Q9BQD3
Y2H Prey Pooling
25416956
种属内
MAP1LC3A Q9H492 KXD1 Homo sapiens Q9BQD3
Y2H Prey Pooling
32296183
种属内
MAP1LC3A Q9H492 NBR1 Homo sapiens Q14596
Pull Down
19250911
种属内
MAP1LC3A Q9H492 NBR1 Homo sapiens Q14596
IF
19427866
种属内
MAP1LC3A Q9H492 NBR1 Homo sapiens Q14596
Pull Down
19427866
种属内
MAP1LC3A Q9H492 TOLLIP Homo sapiens Q9H0E2
Anti Tag CoIP
25042851
种属内
MAP1LC3A Q9H492 VPS9D1 Homo sapiens Q9Y2B5
Y2H Prey Pooling
32296183
种属内
MAP1LC3A Q9H492 VPS9D1 Homo sapiens Q9Y2B5
Validated Y2H
32296183
种属内
MAP1LC3A Q9H492 VPS9D1 Homo sapiens Q9Y2B5
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MAP1LC3A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70916 MAP1LC3A Protein, Human (His) Q9H492-1 (M1-F121) ≥95%

MAP1LC3A 抗体

目录号 产品名 应用 反应物种
HY-P80741 LC3A/B Antibody WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Retinitis Pigmentosa-Deafness Syndrome

Retinitis Pigmentosa 8, Formerly

Rp8, Formerly

Retinitis Pigmentosa 21, Formerly

Rp21, Formerly

Usher Syndrome
Alzheimer Disease 13

AD13

Alzheimer Disease-13

Alzheimer'S Disease 13

Alzheimer'S Disease 13, Late Onset
Cystinosis

Cystine Storage Disease

Cystine Diathesis

Cystine Disease

Cystinoses

Protein Defect Of Cystin Transport

Cystin Transport, Protein Defect Of

Nephropathic Cystinosis

Protein Defect Of Cystine Transport
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08028 MAP1LC3A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MAP1LC3A VGNC VGNC:68152
Canis familiaris MAP1LC3A VGNC VGNC:54324
Macaca mulatta MAP1LC3A VGNC VGNC:95358
Rattus norvegicus MAP1LC3A RGD RGD:735183
Bos taurus MAP1LC3A VGNC VGNC:31179
Mus musculus MAP1LC3A MGD MGI:1915661
Others MAP1LC3A NCBI
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