1. Gene
  2. TEAD2 - TEA domain transcription factor 2 Gene

TEAD2 - TEA domain transcription factor 2 Gene

中文名称:TEA 域转录因子 2

种属: Homo sapiens

同用名: ETF; TEF4; TEF-4; TEAD-2

基因 ID: 8463 | 基因类型: protein coding

关于 TEAD2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,340,595-49,362,416 (from NCBI)

This gene has 10 transcripts (splice variants), 124 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 17.4), ovary (RPKM 10.9) and 24 other tissues.

功能概要

启用多种功能,包括 DNA 结合转录因子活性;无序的域特异性结合活性;和转录辅激活因子结合活性。参与河马信号;转录的正调控,DNA 模板化;和含蛋白质的复杂组装。位于细胞质和核质中。 TEAD-YAP 复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables several functions, including DNA-binding transcription factor activity; disordered domain specific binding activity; and transcription coactivator binding activity. Involved in hippo signaling; positive regulation of transcription, DNA-templated; and protein-containing complex assembly. Located in cytosol and nucleoplasm. Part of TEAD-YAP complex. [provided by Alliance of Genome Resources, Apr 2022]

TEAD2 基因产物(6)

mRNA Protein Name
NM_001256658.2 NP_001243587.1 transcriptional enhancer factor TEF-4 isoform 1
NM_001256659.2 NP_001243588.1 transcriptional enhancer factor TEF-4 isoform 1
NM_001256660.2 NP_001243589.1 transcriptional enhancer factor TEF-4 isoform 2
NM_001256661.2 NP_001243590.1 transcriptional enhancer factor TEF-4 isoform 2
NM_001256662.2 NP_001243591.1 transcriptional enhancer factor TEF-4 isoform 4
NM_003598.2 NP_003589.1 transcriptional enhancer factor TEF-4 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
18579750 GOA
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
20368466 GOA
enables disordered domain specific binding IMP
IMP: 通过突变表型推断
20368466 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18579750 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
20368466 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in hippo signaling IDA
IDA: 通过直接分析推断
18579750 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
20368466 GOA
involved in protein-containing complex assembly IMP
IMP: 通过突变表型推断
20368466 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of TEAD-YAP complex IDA
IDA: 通过直接分析推断
20368466 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TEAD2 蛋白结构

TEA

TEA: TEA/ATTS domain family (20 - 439)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 447 a.a.
蛋白主名 其他名称

transcriptional enhancer factor TEF-4

TEA domain family member 2

TEAD2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TEAD2 Q15562 BCL2L15 Homo sapiens Q5TBC7
Anti Tag CoIP
25416956
种属内
TEAD2 Q15562 BCL2L15 Homo sapiens Q5TBC7
Y2H Array
25416956
种属内
TEAD2 Q15562 YAP1 Homo sapiens P46937
NMR
20368466
种属内
TEAD2 Q15562 YAP1 Homo sapiens P46937
Anti Tag CoIP
33961781
种属内
TEAD2 Q15562 YAP1 Homo sapiens P46937
Pull Down
20368466
种属内
TEAD2 Q15562 YAP1 Homo sapiens P46937
ITC
20368466
种属内
TEAD2 Q15562 YAP1 Homo sapiens P46937
BioID
35140242
种属内
TEAD2 Q15562 USF2 Homo sapiens Q15853
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

TEAD2 抗体

目录号 产品名 应用 反应物种
HY-P82377 Transcriptional Enhancer Factor TEF Antibody (YA2122) WB Human

关联疾病

疾病名称 别名
Sveinsson Chorioretinal Atrophy

SCRA

Atrophia Areata

Helicoid Peripapillary Chorioretinal Degeneration

Hpcd

Aa

Peripapillary Chorioretinal Degeneration, Icelandic Type

Helicoidal Peripapillary Chorioretinal Degeneration

Atrophy, Chorioretinal, Sveinsson

Spastic Paraplegia 24, Autosomal Recessive

SPG24

Spastic Paraplegia 24

Hereditary Spastic Paraplegia 24

Autosomal Recessive Spastic Paraplegia Type 24

Autosomal Recessive Spastic Paraplegia 24

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TEAD2 VGNC VGNC:47229
Mus musculus TEAD2 MGD MGI:104904
Bos taurus TEAD2 VGNC VGNC:35725
Felis catus TEAD2 VGNC VGNC:66054
Rattus norvegicus TEAD2 RGD RGD:1593252
Macaca mulatta TEAD2 VGNC VGNC:78302
Others TEAD2 NCBI