RAE1 - ribonucleic acid export 1 Gene

中文名称：核糖核酸输出 1

种属: Homo sapiens

同用名: Gle2; MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1

关于 RAE1

功能概要

已证明 Schizosaccharomyces pombe Rae1 和 Saccharomyces cerevisiae Gle2 基因的突变会导致含有 poly (A) 的 mRNA 在细胞核中积累，表明编码的蛋白质参与 RNA 输出。该基因编码的蛋白质是酵母 Rae1 的同系物。它包含四个 WD40 基序，并已显示定位到核质中的不同焦点、核边缘和整个细胞质中的网状结构。该基因被认为参与核质转运，并直接或间接地将细胞质 mRNP 连接到细胞骨架。已发现该基因编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the Cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]