LAMTOR3 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Gene

中文名称：晚期内体/溶酶体衔接子、MAPK 和 MTOR 激活子 3

种属: Homo sapiens

同用名: MP1; MAPBP; MAPKSP1; PRO0633; MAP2K1IP1; Ragulator3

关于 LAMTOR3

功能概要

该基因编码一种在细胞外信号调节激酶 (ERK) 级联中起作用的支架蛋白。该蛋白通过丝裂原活化蛋白结合蛋白相互作用蛋白定位于晚期核内体，并特异性结合 MAP 激酶激酶 MAP2K1/MEK1、MAP 激酶 MAPK3/ERK1 和 MAP 激酶 MAPK1/ERK2。对小鼠直向同源基因的研究表明它调节晚期内体运输和细胞增殖。已经观察到该基因编码多种亚型的可变剪接转录物变体。该基因的假基因位于 13 号染色体的长臂上。[RefSeq 提供，2011 年 8 月]

This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]