EIF3G - eukaryotic translation initiation factor 3 subunit G Gene

中文名称：真核翻译起始因子 3 亚基 G

种属: Homo sapiens

同用名: EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta

基因 ID: 8666 | 基因类型: protein coding

关于 EIF3G

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,115,014-10,119,899 (from NCBI)

This gene has 15 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in ovary (RPKM 90.1), testis (RPKM 63.4) and 25 other tissues.

功能概要

该基因编码真核翻译起始因子 3 (eIF3) 复合物的核心亚基，它是蛋白质翻译起始所必需的。编码蛋白的 N 端半胱天冬酶裂解产物可刺激 DNA 降解。该基因的突变与发作性睡病有关。[RefSeq 提供，2016 年 7 月]

This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal Caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]

EIF3G 基因产物(1)

mRNA	Protein	Name
NM_003755.5	NP_003746.2	eukaryotic translation initiation factor 3 subunit G

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA binding	IDA IDA: 通过直接分析推断	25849773	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14688252	GOA
contributes to translation initiation factor activity	IDA IDA: 通过直接分析推断	17581632	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in translational initiation	IDA IDA: 通过直接分析推断	17581632	GOA
involved in viral translational termination-reinitiation	IDA IDA: 通过直接分析推断	21347434	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	12426392	GOA
part of eukaryotic translation initiation factor 3 complex	IDA IDA: 通过直接分析推断	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: 通过物理相互作用推断	17322308	GOA
NOT located in nucleus	IDA IDA: 通过直接分析推断	12426392	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF3G 蛋白结构

eIF3g

RRM_1

0
100
200
300
320 a.a.

蛋白主名

其他名称

eukaryotic translation initiation factor 3 subunit G

eukaryotic translation initiation factor 3 RNA-binding subunit

EIF3G 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	EIF3G	O75821	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
种属内	EIF3G	O75821	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
种属内	EIF3G	O75821	PELO	Homo sapiens	Q9BRX2	Pull Down	20406461
种属内	EIF3G	O75821	PELO	Homo sapiens	Q9BRX2	Anti Tag CoIP	20406461
种属内	EIF3G	O75821	PELO	Homo sapiens	Q9BRX2	Y2H	20406461
种属内	EIF3G	O75821	PELO	Homo sapiens	Q9BRX2	Anti Bait CoIP	20406461
种属内	EIF3G	O75821	PELO	Homo sapiens	Q9BRX2	BiFC	20406461
种属内	EIF3G	O75821	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	EIF3G	O75821	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	EIF3G	O75821	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	EIF3G	O75821	EIF3I	Homo sapiens	Q13347	Anti Tag CoIP	33961781
种属内	EIF3G	O75821	EIF3I	Homo sapiens	Q13347	Anti Tag CoIP	28514442
种属内	EIF3G	O75821	EIF3I	Homo sapiens	Q13347	Anti Tag CoIP	35271311
种属内	EIF3G	O75821	EIF3I	Homo sapiens	Q13347	Y2H Array	17094969
种属内	EIF3G	O75821	EIF3I	Homo sapiens	Q13347	SLCA	18599441
种属内	EIF3G	O75821	AIFM1	Homo sapiens	O95831	Pull Down	17094969
种属内	EIF3G	O75821	AIFM1	Homo sapiens	O95831	Y2H Array	17094969
种属内	EIF3G	O75821	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	33961781
种属内	EIF3G	O75821	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	24396066
种属内	EIF3G	O75821	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	35271311
种属内	EIF3G	O75821	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	EIF3G	O75821	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	EIF3G	O75821	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	EIF3G	O75821	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
种属内	EIF3G	O75821	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
种属内	EIF3G	O75821	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
种属内	EIF3G	O75821	ACD	Homo sapiens	Q96AP0	Pull Down	21044950
种属内	EIF3G	O75821	MIF4GD	Homo sapiens	A9UHW6-2	Y2H Array	32296183
种属内	EIF3G	O75821	MIF4GD	Homo sapiens	A9UHW6-2	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 EIF3G 蛋白

目录号	产品名	蛋白编号	纯度
HY-P700506	EIF3G Protein, Human (His-SUMO)	O75821 (P2-N320)	≥95%

关联疾病

疾病名称

别名

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Cardiomyopathy, Familial Hypertrophic, 15

Hypertrophic Cardiomyopathy 15	CMH15
Cardiomyopathy, Hypertrophic, 15	Cardiomyopathy Familial Hypertrophic 15
Cardiomyopathy, Familial Hypertrophic 15	Cardiomyopathy, Hypertrophic, Familial, Type 15

Craniotubular Dysplasia, Ikegawa Type

CTDI	Craniotubular Dysplasia Ikegawa Type
Doid:0112340

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04263	EIF3G Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	EIF3G	RGD	RGD:1307191
Canis familiaris	EIF3G	VGNC	VGNC:40273
Bos taurus	EIF3G	VGNC	VGNC:28397
Macaca mulatta	EIF3G	VGNC	VGNC:72190
Felis catus	EIF3G	VGNC	VGNC:61783
Mus musculus	EIF3G	MGD	MGI:1858258
Others	EIF3G	NCBI

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