TNK1 - tyrosine kinase non receptor 1 Gene

中文名称：酪氨酸激酶非受体 1

种属: Homo sapiens

同用名: KOS1

关于 TNK1

功能概要

该基因编码的蛋白质属于酪氨酸蛋白激酶家族。酪氨酸蛋白激酶是细胞内信号转导通路的重要调节因子，介导细胞增殖、存活和发育。该基因在胎儿组织中高度表达，在少数成人组织中表达较低，因此可能在胎儿发育过程中广泛使用的信号通路中发挥作用，并在成人组织中更有选择性。它在 Ras-Raf1-MAPK 通路中起着负调节作用，敲除小鼠已被证明会发展为自发性肿瘤，表明它具有抑癌基因的作用。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]