2. Gene
  3. EED - embryonic ectoderm development Gene

EED - embryonic ectoderm development Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胚胎外胚层发育

种属: Homo sapiens

同用名: HEED; COGIS; WAIT1

基因 ID: 8726 | 基因类型: protein coding

关于 EED

Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38): 11:86,244,753-86,287,615 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and is associated with 68 phenotypes. Ubiquitous expression in lymph node (RPKM 3.3), appendix (RPKM 2.2) and 25 other tissues.

功能概要

该基因编码 Polycomb 组 (PcG) 家族的成员。 PcG 家族成员形成多聚体蛋白复合物，参与在连续的细胞世代中维持基因的转录抑制状态。该蛋白与 zeste 2 的增强子、整合素 beta7 的细胞质尾部、1 型免疫缺陷病毒 (HIV-1) MA 蛋白和组蛋白脱乙酰酶蛋白相互作用。这种蛋白质通过组蛋白去乙酰化介导基因活性的抑制，并且可以作为整合素功能的特定调节剂。已经为该基因鉴定了编码不同亚型的两个转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of Integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of Integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

EED 基因产物(3)

mRNA Protein Name
NM_001308007.2 NP_001294936.1 polycomb protein EED isoform c
NM_001330334.2 NP_001317263.1 polycomb protein EED isoform d
NM_003797.5 NP_003788.2 polycomb protein EED isoform a
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme activator activity IDA
IDA: 通过直接分析推断
15385962 GOA
enables enzyme activator activity IMP
IMP: 通过突变表型推断
28229514 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
11124122 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16357870 GOA
enables transcription corepressor binding IPI
IPI: 通过物理相互作用推断
29628311 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ESC/E(Z) complex IDA
IDA: 通过直接分析推断
15385962 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EED 蛋白结构

WD40

WD40: WD domain, G-beta repeat (181 - 219)

WD40

WD40: WD domain, G-beta repeat (233 - 263)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 441 a.a.
蛋白主名 其他名称

polycomb protein EED

WD protein associating with integrin cytoplasmic tails 1

EED 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EED O75530 SUZ12 Homo sapiens Q15022
Anti Tag CoIP
26496610
种属内
EED O75530 SUZ12 Homo sapiens Q15022
Anti Bait CoIP
22439931
种属内
EED O75530 SUZ12 Homo sapiens Q15022
TAP
27705803
种属内
EED O75530 SUZ12 Homo sapiens Q15022
Anti Tag CoIP
21078963
种属内
EED O75530 ASXL1 Homo sapiens Q8IXJ9
Anti Bait CoIP
22897849
种属内
EED O75530 RACK1 Homo sapiens P63244
Y2H
20080539
种属内
EED O75530 DDB1 Homo sapiens Q16531
Anti Bait CoIP
17041588
种属内
EED O75530 CCT3 Homo sapiens P49368
Crosslink
30021884
种属内
EED O75530 CCT3 Homo sapiens P49368
TAP
27705803
种属内
EED O75530 EZH2 Homo sapiens Q15910
Anti Bait CoIP
22439931
种属内
EED O75530 EZH2 Homo sapiens Q15910
Anti Tag CoIP
26496610
种属内
EED O75530 EZH2 Homo sapiens Q15910
Anti Bait CoIP
22897849
种属内
EED O75530 EZH2 Homo sapiens Q15910
TAP
27705803
种属内
EED O75530 DNMT1 Homo sapiens P26358
Anti Bait CoIP
16357870
种属内
EED O75530 DNMT3B Homo sapiens Q9UBC3
Anti Bait CoIP
16357870
种属内
EED O75530 DNMT3B Homo sapiens Q9UBC3
Pull Down
16357870
种属内
EED O75530 EZH1 Homo sapiens Q92800
TAP
27705803
种属内
EED O75530 DNMT3A Homo sapiens Q9Y6K1
Anti Bait CoIP
16357870
种属间
EED O75530 Smpd3 Mus musculus Q9JJY3
Anti Tag CoIP
20080539
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 EED 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74179 EED Protein, Human (sf9, His-GST) O75530 (M1-R441) ≥95%

关联疾病

疾病名称 别名
Cohen-Gibson Syndrome

COGIS
Weaver Syndrome

Wss

Weaver-Smith Syndrome

WVS

Weaver-Like Syndrome

Weaver-Williams Syndrome

Camptodactyly-Overgrowth-Unusual Facies Syndrome

Camptodactyly - Overgrowth - Unusual Facies

Ezh2 Related Overgrowth

Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly

Weaver Smith Syndrome

Weaver Like Syndrome

Weaver Williams Syndrome

Camptodactyly-Overgrowth-Unusual Facies

Weaver Syndrome 1

Weaver Syndrome 2

Wvs1

Wvs2
Atypical Neurofibroma
Diffuse Large B-Cell Lymphoma

Dlbcl

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Large B-Cell Diffuse Lymphoma

Lymphoma, Large B-Cell, Diffuse

Dlbcl - [Diffuse Large B-Cell Lymphoma]

Diffuse Large Beta Cell Lymphoma
Fallopian Tube Endometriosis

Endometriosis Of Fallopian Tube

Adenomyosis Of Fallopian Tube
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-103663 MAK683 Inhibitor 99.18% Phase 2
HY-139400 Pociredir Inhibitor 99.97% Phase 1
HY-158102 ORIC-944 Inhibitor 99.90% Phase 1
HY-139400A Pociredir hydrochloride Inhibitor 99.89% Phase 1
Pre-clinical Phase
生物活性分子 (31)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101117 EED226 Inhibitor 99.65% 否
HY-101512 A-395 Inhibitor 99.12% 否
HY-130708 UNC6852 Inhibitor 99.09% 否
HY-130979 EED226-COOH 98.53% 否
HY-130815A MAK683-CH2CH2COOH hydrochloride Inhibitor 98.03% 否
HY-W014099 Boc-NH-C4-acid 99.85% 否
HY-130615 PROTAC EED degrader-2 Inhibitor 99.90% 否
HY-136977 EEDi-5285 Inhibitor 99.98% 否
HY-130614 PROTAC EED degrader-1 Inhibitor 98.27% 否
HY-W004697 Boc-GABA-OH ≥98.0% 否
HY-132922 EEDi-5273 Inhibitor 99.09% 否
HY-157164 PROTAC EZH2 Degrader-2 Degrader 99.78% 否
HY-158102A ORIC-944 TFA Inhibitor / 否
HY-158239 MS181 Inhibitor 98.36% 否
HY-114176B (S,R,S)-AHPC-C4-NH2 dihydrochloride / 否
HY-132970 EED ligand 1 Inhibitor 99.93% 否
HY-130815 MAK683-CH2CH2COOH Inhibitor / 否
HY-130816 (S,R,S)-AHPC-O-Ph-PEG1-NH2 96.97% 否
HY-114176 (S,R,S)-AHPC-C4-NH2 hydrochloride ≥97.0% 否
HY-103663A MAK683 hydrochloride Inhibitor / 否
HY-130711A (S,R,S)-AHPC-C3-NH2 TFA / 否
HY-114176A (S,R,S)-AHPC-C4-NH2 / 否
HY-130638 (S,R,S)-AHPC-O-Ph-PEG1-NH-Boc / 否
HY-130711 (S,R,S)-AHPC-C3-NH2 / 否
HY-130637 Boc-NH-PEG1-Ph-O-CH2COOH / 否
HY-130711C (S,R,S)-AHPC-C3-NH2 dihydrochloride / 否
HY-160924 MS147 Inhibitor / 否
HY-P2266 SAH-EZH2 Inhibitor / 否
HY-RS04173 EED Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-124660A A-395N / 否
HY-135045 (S,R,S)-AHPC-C4-COOH / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus EED VGNC VGNC:28332
Mus musculus EED MGD MGI:95286
Felis catus EED VGNC VGNC:61731
Macaca mulatta EED VGNC VGNC:72162
Rattus norvegicus EED RGD RGD:1309782
Canis familiaris EED VGNC VGNC:40206
Others EED NCBI
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