2. Gene
  3. ALKBH1 - alkB homolog 1, histone H2A dioxygenase Gene

ALKBH1 - alkB homolog 1, histone H2A dioxygenase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：alkB 同系物 1，组蛋白 H2A 双加氧酶

种属: Homo sapiens

同用名: ABH; ABH1; alkB; hABH; ALKBH

基因 ID: 8846 | 基因类型: protein coding

关于 ALKBH1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,672,404-77,708,023 (from NCBI)

This gene has 4 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in testis (RPKM 4.0), thyroid (RPKM 3.4) and 25 other tissues.

功能概要

该基因编码大肠杆菌 alkB 基因产物的同系物。大肠杆菌 alkB 蛋白是 DNA 烷基化损伤修复适应性反应机制的一部分。它通过 1-甲基腺嘌呤和 3-甲基胞嘧啶的氧化去甲基化参与损伤逆转。[RefSeq 提供，2008 年 7 月]

This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008]

ALKBH1 基因产物(1)

mRNA Protein Name
NM_006020.3 NP_006011.2 nucleic acid dioxygenase ALKBH1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 2-oxoglutarate-dependent dioxygenase activity IDA
IDA: 通过直接分析推断
27497299 GOA
enables broad specificity oxidative DNA demethylase activity IDA
IDA: 通过直接分析推断
18603530 GOA
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
IDA: 通过直接分析推断
19959401 GOA
enables ferrous iron binding IDA
IDA: 通过直接分析推断
18603530 GOA
enables oxidative RNA demethylase activity IDA
IDA: 通过直接分析推断
18603530 GOA
enables tRNA binding IDA
IDA: 通过直接分析推断
27497299 GOA
enables tRNA demethylase activity IDA
IDA: 通过直接分析推断
27745969 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA repair IDA
IDA: 通过直接分析推断
19959401 GOA
involved in oxidative RNA demethylation IDA
IDA: 通过直接分析推断
31188562 GOA
involved in positive regulation of gene expression, epigenetic IDA
IDA: 通过直接分析推断
30017583 GOA
involved in regulation of mitochondrial translation IMP
IMP: 通过突变表型推断
27497299 GOA
involved in regulation of translational elongation IMP
IMP: 通过突变表型推断
27745969 GOA
involved in regulation of translational initiation IMP
IMP: 通过突变表型推断
27745969 GOA
involved in regulation of translational initiation by tRNA modification IDA
IDA: 通过直接分析推断
27745969 GOA
involved in tRNA wobble cytosine modification IDA
IDA: 通过直接分析推断
27497299 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
18603530 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ALKBH1 蛋白结构

2OG-FeII_Oxy_2

2OG-FeII_Oxy_2: 2OG-Fe(II) oxygenase superfamily (99 - 344)

  • 0
  • 100
  • 200
  • 300
  • 389 a.a.
蛋白主名 其他名称

nucleic acid dioxygenase ALKBH1

DNA 6mA demethylase

关联疾病

疾病名称 别名
Plantar Fasciitis

Fasciitis, Plantar
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-163385 ALKBH1-IN-1 98.88% 否
HY-158998 ALKBH1-IN-2 99.16% 否
HY-168044 ALKBH1-IN-3 Activator / 否
HY-169131 ALKBH1-IN-3 prodrug Activator / 否
HY-RS00603 ALKBH1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ALKBH1 VGNC VGNC:69630
Bos taurus ALKBH1 VGNC VGNC:55101
Mus musculus ALKBH1 MGD MGI:2384034
Canis familiaris ALKBH1 VGNC VGNC:50620
Felis catus ALKBH1 VGNC VGNC:81038
Rattus norvegicus ALKBH1 RGD RGD:1308327
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