PRC1 - protein regulator of cytokinesis 1 Gene

中文名称：胞质分裂蛋白调节因子 1

种属: Homo sapiens

同用名: ASE1

关于 PRC1

功能概要

该基因编码一种参与胞质分裂的蛋白质。该蛋白在有丝分裂的 S 期和 G2/M 期以高水平存在，但当细胞退出有丝分裂并进入 G1 期时其水平急剧下降。它在间期位于细胞核中，在有丝分裂期间以高度动态的方式与有丝分裂纺锤体相关，并在胞质分裂期间定位于细胞中体。这种蛋白质已被证明是几种细胞周期蛋白依赖性激酶 (CDK) 的底物。极化平行微管和集中负责收缩环组装的因素是必要的。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 6 月]

This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]