CLDN10 - claudin 10 Gene

中文名称：密蛋白 10

种属: Homo sapiens

同用名: OSPL; HELIX; OSP-L; CPETRL3

基因 ID: 9071 | 基因类型: protein coding

关于 CLDN10

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:95,433,755-95,579,759 (from NCBI)

This gene has 3 transcripts (splice variants), 419 orthologues, 22 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 32.5), salivary gland (RPKM 18.3) and 4 other tissues.

功能概要

该基因编码密蛋白家族的一个成员。 Claudins 是完整的膜蛋白和紧密连接链的组成部分。紧密连接链作为物理屏障，防止溶质和水自由通过上皮或内皮细胞片之间的细胞旁空间，并且在维持细胞极性和信号转导中也起着关键作用。该基因的表达水平与原发性肝细胞癌的复发有关。已经报道了编码不同同种型的六种选择性剪接的转录本变体，但一些变体的转录本序列尚未确定。[RefSeq 提供，2010 年 6 月]

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]

CLDN10 基因产物(3)

mRNA	Protein	Name
NM_001160100.2	NP_001153572.1	claudin-10 isoform a_i1
NM_006984.5	NP_008915.1	claudin-10 isoform b precursor
NM_182848.4	NP_878268.1	claudin-10 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IDA IDA: 通过直接分析推断	28028216	GOA
enables paracellular tight junction channel activity	IDA IDA: 通过直接分析推断	19383724	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in paracellular transport	IDA IDA: 通过直接分析推断	19383724	GOA
involved in regulation of monoatomic ion transport	IMP IMP: 通过突变表型推断	28686597	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	28771254	GOA
located in tight junction	IDA IDA: 通过直接分析推断	19383724	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLDN10 蛋白结构

PMP22_Claudin

0
100
200
228 a.a.

蛋白主名

其他名称

claudin-10

OSP-like protein

CLDN10 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CLDN10	P78369	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
种属内	CLDN10	P78369	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
种属内	CLDN10	P78369	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
种属内	CLDN10	P78369	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
种属内	CLDN10	P78369	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
种属内	CLDN10	P78369	REEP1	Homo sapiens	Q9H902	Y2H Prey Pooling	32296183
种属内	CLDN10	P78369	REEP1	Homo sapiens	Q9H902	Y2H Array	32296183
种属内	CLDN10	P78369	REEP1	Homo sapiens	Q9H902	Validated Y2H	32296183
种属内	CLDN10	P78369	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
种属内	CLDN10	P78369	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
种属内	CLDN10	P78369	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
种属内	CLDN10	P78369	BEST2	Homo sapiens	Q8NFU1	Validated Y2H	32296183
种属内	CLDN10	P78369	BEST2	Homo sapiens	Q8NFU1	Y2H Array	32296183
种属内	CLDN10	P78369	BEST2	Homo sapiens	Q8NFU1	Y2H Prey Pooling	32296183
种属内	CLDN10	P78369	PEX12	Homo sapiens	O00623	Y2H Array	32296183
种属内	CLDN10	P78369	PEX12	Homo sapiens	O00623	Y2H Prey Pooling	32296183
种属内	CLDN10	P78369	TMEM9	Homo sapiens	Q9P0T7	Validated Y2H	32296183
种属内	CLDN10	P78369	TMEM9	Homo sapiens	Q9P0T7	Y2H Array	32296183
种属内	CLDN10	P78369	TMEM9	Homo sapiens	Q9P0T7	Y2H Prey Pooling	32296183
种属内	CLDN10	P78369	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
种属内	CLDN10	P78369	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
种属内	CLDN10	P78369	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Helix Syndrome

HELIX	Hypohidrosis, Electrolyte Imbalance, Lacrimal Gland Dysfunction, Ichthyosis, And Xerostomia
Hypohidrosis-Electrolyte Imbalance-Lacrimal Gland Dysfunction-Ichthyosis-Xerostomia Syndrome

Anhidrosis

Hypohidrosis	Absence Of Sweating
Adiaphoresis	Impaired Sweating
Oligohidrosis

Adenocarcinoma In Situ

Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium	Adenosquamous Carcinoma Of The Endometrium
Endometrial Adenosquamous Cancer	Endometrial Adenosquamous Cell Carcinoma

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Deafness, Autosomal Recessive 29

DFNB29	Autosomal Recessive Nonsyndromic Deafness 29
Autosomal Recessive Deafness 29	Deafness, Autosomal Recessive, 29
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29
Deafness, Autosomal Recessive, Type 29

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02763	CLDN10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CLDN10	VGNC	VGNC:39309
Bos taurus	CLDN10	VGNC	VGNC:27403
Macaca mulatta	CLDN10	VGNC	VGNC:71243
Rattus norvegicus	CLDN10	RGD	RGD:1308027
Mus musculus	CLDN10	MGD	MGI:1913101
Felis catus	CLDN10	VGNC	VGNC:102180

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