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  2. DLGAP2 - DLG associated protein 2 Gene

DLGAP2 - DLG associated protein 2 Gene

中文名称:DLG 相关蛋白 2

种属: Homo sapiens

同用名: DAP2; SAPAP2; C8orf68; ERICH1-AS1

基因 ID: 9228 | 基因类型: protein coding

关于 DLGAP2

Cytogenetic location: 8p23.3 Genomic coordinates (GRCh38): 8:737,628-1,708,476 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 210 orthologues and 4 paralogues. Biased expression in brain (RPKM 4.0), testis (RPKM 1.4) and 2 other tissues.

功能概要

该基因的产物是一种膜相关蛋白,可能在神经元细胞的突触组织和信号传导中发挥作用。该基因在大脑中以双等位基因表达,然而,只有父系等位基因在睾丸中表达 (PMID:18055845) 。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供,2014 年 6 月]

The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2014]

DLGAP2 基因产物(1)

mRNA Protein Name
NM_001346810.2 NP_001333739.1 disks large-associated protein 2 isoform 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DLGAP2 蛋白结构

GKAP

GKAP: Guanylate-kinase-associated protein (GKAP) protein (627 - 975)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 975 a.a.
蛋白主名 其他名称

disks large-associated protein 2

ERICH1 antisense RNA 1 (non-protein coding)

DLGAP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DLGAP2 Q9P1A6 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra DLGAP2 Q9P1A6 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra DLGAP2 Q9P1A6 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
25416956
Intra DLGAP2 Q9P1A6 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
Intra DLGAP2 Q9P1A6 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra DLGAP2 Q9P1A6 GRB2 Homo sapiens P62993
Peptide Array
17474147
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Tardive Dyskinesia

Drug-Induced Tardive Dyskinesia

Lingual-Facial-Buccal Dyskinesia

Neuroleptic-Induced Tardive Dyskinesia

Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior

Mobitz Type Ii Atrioventricular Block

Mobitz Ii Atrioventricular Block

Mobitz Ii Atrioventricular Block

Ceroid Lipofuscinosis, Neuronal, 8, Northern Epilepsy Variant

Northern Epilepsy

Neuronal Ceroid Lipofuscinosis 8 Northern Epilepsy Variant

Epmr

Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type

Northern Epilepsy Syndrome

Epilepsy, Progressive, With Mental Retardation

Northern Epilepsy Variant, Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant

Progressive Epilepsy With Mental Retardation, Northern Epilepsy

Cln8 Disease, Northern Epilepsy Variant

Ncl, Northern Epilepsy Variant

Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant

CLN8NE

Ceroid Lipofuscinosis, Neuronal, 8

Trichotillomania

TTM

Hair-Pulling Syndrome

Compulsive Hair Plucking

Hair Pulling Disorder

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Separation Anxiety Disorder

Separation Anxiety Disorder Of Childhood

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DLGAP2 VGNC VGNC:39980
Rattus norvegicus DLGAP2 RGD RGD:620224
Mus musculus DLGAP2 MGD MGI:2443181
Macaca mulatta DLGAP2 VGNC VGNC:104447
Felis catus DLGAP2 VGNC VGNC:61514