UBE2L6 - ubiquitin conjugating enzyme E2 L6 Gene

中文名称：泛素结合酶 E2 L6

种属: Homo sapiens

同用名: RIG-B; UBCH8

关于 UBE2L6

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶 (E1s) 、泛素结合酶 (E2s) 和泛素蛋白连接酶 (E3s) 。该基因编码 E2 泛素结合酶家族的成员。该酶在一级结构上与 UBE2L3 基因编码的酶高度相似。已经为该基因发现了编码不同亚型的两个可变剪接的转录物变体。[RefSeq 提供，2011 年 5 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes (E1s), ubiquitin-conjugating Enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme is highly similar in primary structure to the Enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]