2. Gene
  3. MAPK8IP1 - mitogen-activated protein kinase 8 interacting protein 1 Gene

MAPK8IP1 - mitogen-activated protein kinase 8 interacting protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶 8 相互作用蛋白 1

种属: Homo sapiens

同用名: IB1; JIP1; JIP-1; PRKM8IP

基因 ID: 9479 | 基因类型: protein coding

关于 MAPK8IP1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:45,885,651-45,906,465 (from NCBI)

This gene has 3 transcripts (splice variants), 285 orthologues, 11 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 54.8), testis (RPKM 11.7) and 5 other tissues.

功能概要

该基因编码胰腺 β 细胞功能的调节剂。它与 JIP-1 高度相似，JIP-1 是一种小鼠蛋白，已知是 c-Jun 氨基末端激酶 (Mapk8) 的调节因子。该蛋白已被证明可以阻止 MAPK8 介导的转录因子激活，并减少 IL-1 β 和 MAP 激酶激酶 1 (MEKK1) 诱导的胰腺 β 细胞凋亡。该蛋白质还充当葡萄糖转运蛋白 GLUT2 的 DNA 结合反式激活因子。据报道，RE1 沉默转录因子 (REST) 可抑制该基因在分泌胰岛素的 β 细胞中的表达。该基因被发现在 2 型糖尿病家族中发生突变，因此被认为是 2 型糖尿病的易感基因。[RefSeq 提供，2011 年 5 月]

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced Apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

MAPK8IP1 基因产物(1)

mRNA Protein Name
NM_005456.4 NP_005447.1 C-Jun-amino-terminal kinase-interacting protein 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MAP-kinase scaffold activity IPI
IPI: 通过物理相互作用推断
11238452 GOA
enables kinesin binding IPI
IPI: 通过物理相互作用推断
11238452 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11517249 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10574993 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAPK8IP1 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (495 - 543)

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (567 - 700)

  • 0
  • 200
  • 400
  • 600
  • 711 a.a.
蛋白主名 其他名称

C-Jun-amino-terminal kinase-interacting protein 1

IB-1

MAPK8IP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAPK8IP1 Q9UQF2 MAPK8 Homo sapiens P45983
Pull Down
18286207
种属内
MAPK8IP1 Q9UQF2 MAPK8 Homo sapiens P45983
GMS
18286207
种属内
MAPK8IP1 Q9UQF2 MAPK8 Homo sapiens P45983
Anti Tag CoIP
33961781
种属内
MAPK8IP1 Q9UQF2 EGFR Homo sapiens P00533
Protein Array
16273093
种属内
MAPK8IP1 Q9UQF2 MAP3K7 Homo sapiens O43318
Pull Down
18286207
种属内
MAPK8IP1 Q9UQF2 MAP3K7 Homo sapiens O43318
GMS
18286207
种属内
MAPK8IP1 Q9UQF2 MAP2K7 Homo sapiens O14733
Pull Down
16840345
种属内
MAPK8IP1 Q9UQF2 MAP2K7 Homo sapiens O14733
GMS
18286207
种属内
MAPK8IP1 Q9UQF2 MAP2K7 Homo sapiens O14733
Pull Down
18286207
种属内
MAPK8IP1 Q9UQF2 ERBB2 Homo sapiens P04626
Protein Array
16273093
种属内
MAPK8IP1 Q9UQF2 APP Homo sapiens P05067
Y2H
11724784
种属内
MAPK8IP1 Q9UQF2 APP Homo sapiens P05067
FRET
11724784
种属内
MAPK8IP1 Q9UQF2 APP Homo sapiens P05067
Pull Down
11724784
种属间
MAPK8IP1 Q9UQF2 App Mus musculus P12023
Y2H
11517249
种属间
MAPK8IP1 Q9UQF2 App Mus musculus P12023
CoIP
11517249
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Papillary Squamous Carcinoma

Papillary Epidermoid Carcinoma

Papillary Squamous Cell Carcinoma
Cervix Erosion

Erosion Of Cervix

Uterine Cervical Erosion
Cervical Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Cervix

Adenosquamous Cell Carcinoma Of The Cervix Uteri
Lymphocele

Lymph Cyst

Lymphocele Adverse Event
Cervix Small Cell Carcinoma

Small Cell Carcinoma Of The Cervix

Small Cell Carcinoma Of The Cervix Uteri
Ischemia

Acute Coronary Syndrome
Vaginal Cancer

Malignant Neoplasm Of Vagina

Vaginal Neoplasms

Malignant Tumor Of Vagina

Malignant Vaginal Tumor

Neoplasm Of Vagina

Vagina Neoplasm

Vaginal Tumor

Vaginal Carcinoma

Vaginal Malignant Epithelial Tumor

Vaginal Neoplasm

Malignant Vaginal Neoplasm

Vagina Carcinoma

Vaginal Neoplasia

Cancer Of Vagina

Malignant Tumour Of Vagina

Carcinoma Of Vagina

Primary Malignant Neoplasm Of Vagina

Vagina Wall Cancer

Vaginal Wall Cancer
Hemometra

Hematometra
Cervical Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of The Cervix Uteri
Cervix Endometriosis

Endometriosis Of Cervix

Cervical Endometriosis
Sigmoid Disease

Sigmoid Diseases
Cervical Incompetence

Uterine Cervical Incompetence
Vaginal Discharge
Cervical Adenoid Basal Carcinoma
Cervical Carcinosarcoma

Cervical Malignant Mixed Mesodermal Mullerian Tumor

Cervical Malignant Mixed Mullerian Tumor

Cervical Mixed Epithelial And Mesenchymal Neoplasm
Cervical Mucinous Adenocarcinoma
Isthmus Cancer
Endocervical Carcinoma

Carcinoma Of Endocervix

Carcinoma Of The Endocervix
Radiation Cystitis

Irradiation Cystitis
Cervix Carcinoma

Cancer Of Cervix

Carcinoma Of Cervix

Carcinoma Cervix Uteri

Carcinoma Of The Cervix Uteri
Cervical Polyp

Cervix Adenomatous Polyp
Uterus Carcinoma In Situ
Anal Canal Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Anal Canal
Cervix Uteri Carcinoma In Situ

Carcinoma In Situ Of Cervix

Carcinoma In Situ Of Uterine Cervix

Cervical Intraepithelial Neoplasia

Carcinoma Of Cervix Stage 0

Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia

Cervix Ca In Situ

Cin Iii

Cin Iii - Carcinoma In Situ Of Cervix

Cin Iii - Severe Dyskaryosis

Severe Dysplasia Of Cervix

Severe Dysplasia Of The Cervix Uteri

Squamous Intraepithelial Neoplasia, Grade Iii

Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7
Cancerophobia

Cancer Phobia

Fear Of Getting Cancer
Adenosquamous Carcinoma

Adenosquamous Cell Carcinoma

Mixed Adenocarcinoma And Squamous Carcinoma

Carcinoma Adenosquamous

Carcinoma, Adenosquamous
Ovarian Melanoma
Nosophobia
Botryoid Rhabdomyosarcoma

Sarcoma Botryoides

Botryoid Sarcoma

Botryoid-Type Embryonal Rhabdomyosarcoma
Adenocarcinoma In Situ
Cervical Adenocarcinoma

Adenocarcinoma Cervix Uteri

Adenocarcinoma Of Cervix

Adenocarcinoma Of The Uterine Cervix

Adenocarcinoma Of The Cervix Uteri
Endocervical Adenocarcinoma

Endocervical Carcinoma
Endometrial Small Cell Carcinoma
Cervix Disease

Uterine Cervical Diseases

Cervix Disorders

Cervix Diseases
Vaginal Disease

Vaginal Diseases
Cervical Adenosarcoma

Cervical Muellerian Adenosarcoma

Cervical Mullerian Adenosarcoma
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08124 MAPK8IP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MAPK8IP1 VGNC VGNC:49920
Mus musculus MAPK8IP1 MGD MGI:1309464
Felis catus MAPK8IP1 VGNC VGNC:82019
Rattus norvegicus MAPK8IP1 RGD RGD:70937
Bos taurus MAPK8IP1 VGNC VGNC:31224
Macaca mulatta MAPK8IP1 VGNC VGNC:74650
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z