PCLAF - PCNA clamp associated factor Gene

中文名称：PCNA 钳相关因子

种属: Homo sapiens

同用名: L5; PAF; OEATC; PAF15; OEATC1; p15PAF; NS5ATP9; OEATC-1; p15/PAF; KIAA0101; p15(PAF)

基因 ID: 9768 | 基因类型: protein coding

关于 PCLAF

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:64,364,304-64,387,687 (from NCBI)

This gene has 8 transcripts (splice variants) and 196 orthologues. Biased expression in bone marrow (RPKM 26.4), lymph node (RPKM 13.8) and 11 other tissues.

功能概要

启用染色质结合活性。参与多个过程，包括细胞大分子生物合成过程；中心体循环；和对紫外线的反应。位于中心体；核;和细胞质的核周区。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin binding activity. Involved in several processes, including cellular macromolecule biosynthetic process; centrosome cycle; and response to UV. Located in centrosome; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PCLAF 基因产物(2)

mRNA	Protein	Name
NM_001029989.3	NP_001025160.1	PCNA-associated factor isoform 2
NM_014736.6	NP_055551.1	PCNA-associated factor isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables chromatin binding	IDA IDA: 通过直接分析推断	23000965	GOA
enables molecular adaptor activity	EXP EXP: 通过实验结果推断	25762514	GOA
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	25762514	GOA
enables molecular adaptor activity	IPI IPI: 通过物理相互作用推断	25762514	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21628590	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IDA IDA: 通过直接分析推断	21628590	GOA
involved in DNA replication	IDA IDA: 通过直接分析推断	23000965	GOA
involved in centrosome cycle	IMP IMP: 通过突变表型推断	21673012	GOA
involved in regulation of cell cycle	IMP IMP: 通过突变表型推断	21628590	GOA
involved in response to UV	IDA IDA: 通过直接分析推断	23000965	GOA
involved in translesion synthesis	IMP IMP: 通过突变表型推断	23000965	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	21628590	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	21673012	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

PCNA-associated factor

HCV NS5A-transactivated protein 9

PCLAF 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PCLAF	Q15004	PCNA	Homo sapiens	P12004	Y2H Array	32296183
种属内	PCLAF	Q15004	PCNA	Homo sapiens	P12004	Y2H Prey Pooling	32296183
种属内	PCLAF	Q15004	TERF1	Homo sapiens	P54274-2	Y2H Prey Pooling	32296183
种属内	PCLAF	Q15004	TERF1	Homo sapiens	P54274-2	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PCLAF 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75900	KIAA0101 Protein, Human (His)	Q15004-1 (M1-E111)	≥95%

关联疾病

疾病名称

别名

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Phlyctenulosis

Phlyctenular Keratoconjunctivitis

Strumous Ophthalmia

Anomalous Left Coronary Artery From The Pulmonary Artery

Bland White Garland Syndrome	Alcapa
Bland-White-Garland Syndrome	White-Garland Syndrome

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-149428	AD4		98.01%	否
HY-162393	XL44	Activator	98.00%	否
HY-RS10154	PCLAF Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PCLAF	MGD	MGI:1915276
Rattus norvegicus	PCLAF	RGD	RGD:1303041
Others	PCLAF	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PCLAF - PCNA clamp associated factor Gene

关于 PCLAF

功能概要

PCLAF 基因产物(2)

PCLAF 蛋白互作信息

重组 PCLAF 蛋白

关联疾病

直系同源

热门区域

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PCLAF - PCNA clamp associated factor Gene

关于 PCLAF

功能概要

PCLAF 基因产物(2)

PCLAF 蛋白互作信息

重组 PCLAF 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z