2. PI3K/Akt/mTOR Stem Cell/Wnt Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Cell Cycle/DNA Damage
  3. GSK-3 β-catenin DYRK JNK CDK CDKL
  4. GSK3-IN-10

GSK3-IN-10 (Compound 4) 是一种多靶点抑制剂，主要作用于 GSK3α 和 GSK3β，IC50 分别为 1.0 nM 和 2.0 nM。GSK3-IN-10 抑制 β-catenin 的活化，促进神经元存活，并对内质网应激具有保护作用。

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GSK3-IN-10 Chemical Structure

GSK3-IN-10 Chemical Structure

CAS No. : 844441-56-1

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GSK3-IN-10 相关抗体

Top Publications Citing Use of Products

查看 GSK-3 亚型特异性产品:

查看所有亚型
GSK-3 GSK-3α GSK-3β

查看 DYRK 亚型特异性产品:

查看所有亚型
DYRK1 DYRK2 DYRK3 DYRK4

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK3-IN-10 (Compound 4) is a multi-target inhibitor, that mainly targets GSK3α and GSK3β with IC50 of 1.0 nM and 2.0 nM. GSK3-IN-10 inhibits the activation of β-catenin, promotes the neuronal survival, and exhibits a protective effect against endoplasmic reticulum stress[1].

IC50 & Target

GSK-3α

1.0 nM (IC50)

GSK-3β

2.0 nM (IC50)

DYRK1B

47 nM (IC50)

DYRK1A

170 nM (IC50)

ICK

520 nM (IC50)

CLK1

620 nM (IC50)

CLK4

760 nM (IC50)

DYRK2

800 nM (IC50)

CLK2

800 nM (IC50)

CDKL5

840 nM (IC50)

JNK3

2900 nM (IC50)

CDK4

3800 nM (IC50)

分子量

364.35

Formula

C17H18F2N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK3-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK3-IN-10844441-56-1GSK-3β-cateninDYRKJNKCDKCDKLGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinasec-Jun N-terminal kinaseCyclin dependent kinaseCyclin-dependent kinase-like familyInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-172198
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