2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  3. VEGFR Carbonic Anhydrase
  4. hCA/VEGFR-2-IN-2

hCA/VEGFR-2-IN-2 (compound 8g) 是一种吲哚酮基苯磺酰胺，也是癌症相关 hCA IX/XII 和 VEGFR-2 的潜在双重抑制剂。hCA/VEGFR-2-IN-2 抑制 VEGFR-2 (IC50=204 nM)，对 hCAs 具有高结合活性，Ki 分别为 3.6 nM (hCA IX)，16.1 nM (hCA II)，16.7 nM (hCA XII)，75.3 nM (hCA I)。hCA/VEGFR-2-IN-2 对 VEGFR-2 过表达的乳腺癌细胞具有抗增殖活性。

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hCA/VEGFR-2-IN-2 Chemical Structure

hCA/VEGFR-2-IN-2 Chemical Structure

CAS No. : 2971782-66-6

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hCA/VEGFR-2-IN-2 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCA/VEGFR-2-IN-2 (compound 8g) is an indolinonylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-2 inhibits VEGFR-2 (IC50=204 nM) and has high binding activity to hCAs, with Kis of 3.6 nM (hCA IX), 16.1 nM (hCA II), 16.7 nM (hCA XII), and 75.3 nM (hCA I), respectively. hCA/VEGFR-2-IN-2 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells[1].

IC50 & Target

IC50: 204 nM (VEGFR-2), 3.6 nM (hCA IX), 16.1 nM (hCA II), 16.7 nM (hCA XII), 75.3 nM (hCA I)[1]
体内研究
(In Vivo)

hCA/VEGFR-2-IN-2 (compound 8g)

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

498.55

Formula

C23H26N6O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hCA/VEGFR-2-IN-2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCA/VEGFR-2-IN-22971782-66-6VEGFRCarbonic AnhydraseVascular endothelial growth factor receptorCarbonate dehydrataseAngiogenesisAnticancer agentsHypoxic tumorsMolecular modelingTail approachVEGFR-2 inhibitorsInhibitorinhibitorinhibit

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