2. Protein Tyrosine Kinase/RTK Metabolic Enzyme/Protease
  3. VEGFR Carbonic Anhydrase
  4. hCA/VEGFR-2-IN-3

hCA/VEGFR-2-IN-3 (compound 8j) 是一种吲哚酮基苯磺酰胺，也是癌症相关 hCA IX/XII 和 VEGFR-2 的潜在双重抑制剂。hCA/VEGFR-2-IN-3 抑制 VEGFR-2 (IC50=358 nM)， 对 hCAs 具有高结合活性，Ki 分别为 4.2 nM (hCA IX)，22.9 nM (hCA II)，25.1 nM (hCA I)，28.0 nM (hCA XII)。hCA/VEGFR-2-IN-3 对 VEGFR-2 过表达的乳腺癌细胞具有抗增殖活性。

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hCA/VEGFR-2-IN-3 Chemical Structure

hCA/VEGFR-2-IN-3 Chemical Structure

CAS No. : 2971782-73-5

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hCA/VEGFR-2-IN-3 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-3 inhibits VEGFR-2 (IC50=358 nM), has high binding activity to hCAs with Ki of 4.2 nM (hCA IX), 22.9 nM (hCA II), 25.1 nM (hCA I), 28.0 nM (hCA XII), respectively. hCA/VEGFR-2-IN-3 has antiproliferative activity against VEGFR-2 overexpressing breast cancer cells[1].

IC50 & Target

IC50: 358 nM (VEGFR-2), 4.2 nM (hCA IX), 22.9 nM (hCA II), 25.1 nM (hCA I), 28.0 nM (hCA XII)[1]
体内研究
(In Vivo)

hCA/VEGFR-2-IN-3 (compound 8j)

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

528.58

Formula

C24H28N6O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hCA/VEGFR-2-IN-3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCA/VEGFR-2-IN-32971782-73-5VEGFRCarbonic AnhydraseVascular endothelial growth factor receptorCarbonate dehydrataseAngiogenesisAnticancer agentsHypoxic tumorsMolecular modelingTail approachVEGFR-2 inhibitorsInhibitorinhibitorinhibit

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