2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. hCAI/II-IN-2

hCAI/II-IN-2 (compound 2b) 是一种有效的双重 hCA I/II 抑制剂，对于 hCA I、hCA II 和 hCAⅨ，Ki 值分别为 40.97、15.15 和 61.88 nM。hCAI/II-IN-2 具有抗急性高原病 (AMS) 的低氧活性和低细胞活性。

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hCAI/II-IN-2 Chemical Structure

hCAI/II-IN-2 Chemical Structure

CAS No. : 2480283-75-6

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hCAI/II-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

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CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCAI/II-IN-2 (compound 2b) is a potent dual hCA I/II inhibitor with Ki values of 40.97, 15.15 and 61.88 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-2 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity[1].

体外研究
(In Vitro)

hCAI/II-IN-2 (compound 2b) (5-200 μM, 48 hours; HEK293T cells) has no obvious toxicity at HEK293T cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hCAI/II-IN-2 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Embryonic kidney (HEK293T) cells
Concentration: 5, 25, 50, 100 and 200 μM
Incubation Time: 48 hours
Result: Had no apparent cytotoxicity.
体内研究
(In Vivo)
Animal Model: Male BLAB/c mice[1]
Dosage: 400 mg/kg
Administration: Oral administration; 14 days.
Result: Prolonged the survival time of mice by 21.7% compared with the blank control group.
分子量

356.38

Formula

C12H12N4O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hCAI/II-IN-2 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAI/II-IN-22480283-75-6Carbonic AnhydraseCarbonate dehydrataseanti-hypoxiccarbonic anhydrasedual hCA I/II inhibitorInhibitorinhibitorinhibit

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目录号：
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