2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. hCAIX-IN-10

hCAIX-IN-10 (Compound 6i) 是一种选择性碳酸酐酶 (carbonic anhydrase) IX 和 XII 抑制剂，对 hCA IX 和 hCA XII 的 Ki 分别为 61.5 和 586.8 nM。hCA IX 和 hCA XII 是跨膜同工型碳酸酐酶，可作为一些类型肿瘤的生物标志物。hCA XII 有助于维持正常细胞和肿瘤细胞中的酸碱平衡。

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hCAIX-IN-10 Chemical Structure

hCAIX-IN-10 Chemical Structure

CAS No. : 2497504-72-8

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hCAIX-IN-10 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively.  hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].

IC50 & Target

Ki: 61.5 nM (hCA IX), 586.8 nM (hCA XII)[1]
体外研究
(In Vitro)

hCAIX-IN-10 (compound 6i) is a strong inhibitor of hCA IX rather than hCA XII in vitro[1].
hCAIX-IN-10 (0.1 nM-0.1 mM; 6 h) inhibits carbonic anhydrases enzyme activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hCAIX-IN-10 相关抗体:
分子量

479.55

Formula

C28H21N3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hCAIX-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX-IN-102497504-72-8Carbonic AnhydraseCarbonate dehydratasecarbonic anhydrasetransmembranebiomarkertumorInhibitorinhibitorinhibit

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产品名称：
hCAIX-IN-10
目录号：
HY-147827
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